[extropy-chat] Snuppy, frst dog cloned

[Mike Lorrey]

A researcher interviewed on the Smuppy story on tv last night said
their success rate for the dog was 0.9%, i.e. they had about 109
failures before they got one right, and they still don't know if there
will be developmental problems with Smuppy as Ian Wilmut had reported
with Dolly.
One might attribute their failure rate to rookie inexperience and
presume they'll get the rate down significantly. We'll see.

Anything Genetic Savings and Clone announces should be taken with a
massive grain of salt...

--- Giu1i0 Pri5c0 <pgptag at gmail.com> wrote:

> I love my doggy Sacha <http://prisco.info/sacha/> very much and would
> clone 
> her if given the chance. And I think once pet cloning technology is
> refined 
> and deployed commercially, there will be a profitable market niche
> for 
> companies like Genetic Savings and Clone (link below). And, I don't
> see 
> anything wrong with this. But of course, the main value of end-to-end
> 
> cloning research will be a better understanding of biology that can
> be used 
> to improve the quality of life of human patients.
> The Scientist <http://www.the-scientist.com/news/20050803/01>: Move
> over, 
> Fluffy; cloning isn't just for
> cats<http://www.the-scientist.com/2004/10/25/12/1>anymore. The South
> Korean researchers who announced
> earlier this year <http://www.biomedcentral.com/pubmed/14963337> that
> they 
> had successfully derived stem cells from a cloned human embryo have
> now created 
> the first-ever dog clone, a male Afghan hound, they
> report<http://www.nature.com>in
> *Nature* this week.
> Hwang attributed his team's success to their ability to produce a
> nuclear 
> transfer construct using in vivo matured oocytes, to transfer it into
> a 
> surrogate mother at an early stage of development without in vitro
> embryo 
> culture, and to optimize the conditions for transfer "through trial
> and 
> error."
> The team chose an Afghan hound because the dog was known to have a
> "gentle 
> and docile pedigree," Hwang said. They also had access to a good
> collection 
> of photos of the dog, which had unique fur color and appearance, when
> it was 
> a puppy, he said, making it easier to distinguish whether the clone
> was 
> identical. Microsatellite analysis of genomic DNA from the donor, the
> cloned 
> dogs, and the surrogates confirmed that the clones were genetically 
> identical to the donor.
> Phil Damiani, chief scientific officer of Genetic Savings &
> Clone<http://www.savingsandclone.com/>,
> said that his company remained convinced that their technology -
> which 
> relies on chromatin transfer
> <http://www.biomedcentral.com/pubmed/13679310>, 
> rather than nuclear transfer, and egg and embryo assessment prior to
> cloning 
> and transfer–would eventually make it possible to clone dogs
> commercially<http://www.the-scientist.com/2005/1/31/41/1>.
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> 


Mike Lorrey
Vice-Chair, 2nd District, Libertarian Party of NH
"Necessity is the plea for every infringement of human freedom.
It is the argument of tyrants; it is the creed of slaves."
                                      -William Pitt (1759-1806) 
Blog: http://intlib.blogspot.com

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