[ExI] Jaw-dropping CWRU Alzheimer's breakthrough?

[The Avantguardian]

----- Original Message -----
> From: spike <spike66 at att.net>
> To: 'ExI chat list' <extropy-chat at lists.extropy.org>
> Cc: 
> Sent: Friday, February 10, 2012 8:25 AM
> Subject: Re: [ExI] Jaw-dropping CWRU Alzheimer's breakthrough?
> 
> This is one of those cases where there will be volunteers lining up for
> miles for the first study that offers this stuff.  Alzheimers patients have
> absolutely nothing to lose, and their lives to regain.  None of the articles
> flying about on the internet in the last couple days have said how much it
> costs to make this stuff, but if they would tell me, I would personally kick
> in a few thousand bucks to make a gallon or two, and have a relative start
> drinking it down.
> 
> Anyone found any info on how to synthesize bexarotene?  The dopers somehow
> make in their home labs meth-a-whatever-that-stuff-is to get stoned, so can
> we grab their chemical expertise and hire them to cook us up some of this
> bexarotene?  We will overlook that other business, and this will give them a
> chance to use their chemistry talent for something constructive.

Spike, looking at the chemical structure, it looks it would be time-consuming to manufacture by a DIY. The online prices you are finding are for the pharmaceutical grade stuff precisely dosed for cancer treatment. Rather than have a chemist start from scratch to synthesize bexarotene, I recommend you inquire as to the price of the industrial grade stuff which usually much cheaper and available by the kilogram from chemical companies all over the world. I found two in China that have it in their catalog but you have to inquire as to the price. I think the suppliers are all in China because of patent issues. In any case, I can't imagine how a state-side DIY chemist could do any cheaper or better.

Once you have the bulk product, then hire a drug chemist to QC the product from China and purify it to pharmaceutical grade. I think this would be your cheapest route, Spike.


Here is the information you will need for that:

IUPAC Name: 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl]benzoic acid

CAS Number: 153559-49-0 


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Stuart LaForge