[ExI] Jaw-dropping CWRU Alzheimer's breakthrough?

Ilia Stambler ilia.stambler at gmail.com
Sat Feb 18 07:32:24 UTC 2012

 >“It is maddening difficult to tell if these medications work.”

It is very sad that we live in a time and milieu where physicians and
pharmaceutical industry, biomedical research establishment and popular and
special press, are not to be trusted, and where the responsibility for
testing and advancing new therapies lies with individual enthusiasts.
Really sad. But is it hopeless?

On Sat, Feb 18, 2012 at 7:47 AM, spike <spike66 at att.net> wrote:

> On Behalf Of Rafal Smigrodzki
> Subject: Re: [ExI] Jaw-dropping CWRU Alzheimer's breakthrough?
> Any work done in amyloid mice is likely to be useless - the models are
> wrong
> on many levels, from the fact that they are using mutated proteins (which
> are almost always absent in senile dementia), to using combinations of
> mutated proteins (which almost never happens in senile dementia), to the
> lack of pathology in response to the mutated proteins (which indicates the
> mouse's brain reacts differently on the biochemical level than human
> brain).
> These mice have essentially no construct validity for senile dementia,
> misleadingly called "Alzheimer's disease", and only poor to middling
> construct validity for the true Alzheimer's dementia which is a very
> uncommon familial disease affecting young and middle age adults.
> Save your money, until you see results in aged dogs or monkeys (not
> mutated). If somebody publishes a non-human primate study showing a good
> cognitive boost in 25 year old rhesus monkeys, I would be very impressed.
> Rafal
> _______________________________________________
> Thanks Rafal, I came to the same conclusion with great regret.  It has been
> a week since the news hit.  I have been scouring the internet almost
> constantly to see if anyone had taken some of this stuff, and if so what
> happened.  The silence on the topic was deafening.  So I had to conclude
> that of the estimated perhaps a thousand people who managed to get
> Targretin
> in the past week, none saw any positive results.  Otherwise they would have
> posted it in the usual places, and I would have found them by now.  It
> surprises me that no one took some and imagined positive results, but I
> can't find even that.  I sometimes think imagined positive results are how
> we ended up with the apparently useless Aricept and the possibly worse than
> nothing Namenda.  But how the hell can we know for sure?  It is maddening
> difficult to tell if these medications work.
> spike
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