[ExI] Jaw-dropping CWRU Alzheimer's breakthrough?

[The Avantguardian]

 ----- Original Message -----
> From: spike <spike66 at att.net>
> To: 'ExI chat list' <extropy-chat at lists.extropy.org>
> Cc: 
> Sent: Thursday, March 15, 2012 2:32 PM
> Subject: Re: [ExI] Jaw-dropping CWRU Alzheimer's breakthrough?

[snip]
> However the medics know how to increase the crossing rate without wrecking
> the medication, and are working the problem as fast as they can, and may it
> be faster still.  Apparently the miraculous impact of bexarotene on mice is
> not seen to the same degree in humans, or at least not nearly as quickly.
> Damn.

Is there any data about intracranial bexarotene administration in mice? You might be able to deliver it by lumbar puncture directly into the spine or epidural space. That would get the drug directly into the cerebrospinal fluid and the blood brain barrier would be less of an issue. It does carry more risk but how desperate is the situation?

Stuart LaForge


"The state that separates its scholars from its warriors will have its thinking done by cowards, and its fighting by fools." -Thucydides.