[ExI] Jaw-dropping CWRU Alzheimer's breakthrough?

Brian Manning Delaney listsb at infinitefaculty.org
Wed Oct 3 11:56:14 UTC 2012

El 2012-02-27 19:24, Jeff Davis escribió:
> 2012/2/26 spike <spike66 at att.net>:

>From Wikipedia re bexarotene this comment:
> Mechanism
> Bexarotene is a retinoid specifically selective for retinoid X receptors,...
> RXRs are located primarily in visceral organs such as the liver and kidney.
>                         ***********************
> As the CWRU study shows efficacy on the other side of the murine BBB,
> we can conclude that either bexarotene crosses the murine BBB, or that
> it doesn't need to.  That ApoE is upregulated and reduces dissolved
> amyloid beta levels where that is (presumably) needed, is
> demonstrated.  Start there, re its effect across the human BBB, and go
> and collect some (human) data.

Still continuing my research into AD. I'm gathering info for a few close 
friends with early diagnoses of AD, and someone younger (pushing 50) who 
just found out he's an ApoE-ε4 homozygote. (And man, was I slow to 
realize how radically personal genomics is going to change medicine!) 
What does being ε4/ε4 mean? Well, it may mean that bexarotene would make 
things WORSE. We don't know just yet, but I wouldn't take bexarotene if 
I knew I were an ApoE-ε4 homozygote, because I wouldn't want elevated 
levels of ApoE-ε4.

Be careful.


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