[ExI] Medical power of attorney for cryonicsts

[BillK]

On Fri, Dec 5, 2014 at 4:28 AM, spike  wrote:
<snip>
> Summary: what I now think is that I am good to go with this experiment, or
> at least to propose it to the patient's son.  Does anyone here think
> otherwise?
>

As you might expect, the authors of the Bexarotene mouse studies are
very keen to proceed to human trials as quickly as possible. But there
is a lot more involved than just spooning it into a willing open
mouth.

<http://gel-server1.cwru.edu/>

Quote:

Requests for Clinical Trials

We have received hundreds of emails and phone calls about clinical
trials. We are sorry that we are unable to respond individually to
each query.

A phase I proof of mechanism trial will start soon to test the effect
of the drug in the brains of normal subjects. We are not accepting
additional subjects for this trial

We are currently determining how best to administer the drug and
resolve several scientific issues. These studies will take some time
and we are working as fast as our resources allow. These studies must
be completed before we can design a Phase II trial. We do not know
when we can begin these latter trials.

We STRONGLY DISCOURAGE any off label usage of bexarotene. There are
potential serious adverse effects in individuals with diagnosed
Alzheimer's disease.
----------------

What next?
We are currently investigating how best to deliver bexarotene. Our
preliminary work demonstrates that the drug will be optimally
efficacious at levels lower than the FDA-approved dosage. Moreover, we
do not know how frequently to administer the drug to mice. This work
is essential before advancing to Phase II clinical trials and will
take some time to complete. We are also investigating new drug
candidates.

----------------------------


I suspect the above statement could apply to every possible treatment
for Alzheimers. People are desperate. They will try anything that
might help. But their attempts may cause more damage instead of
helping.

BillK