[ExI] book

Rafal Smigrodzki rafal.smigrodzki at gmail.com
Mon Sep 5 01:50:10 UTC 2016

On Wed, Aug 17, 2016 at 11:27 AM, Dave Sill <sparge at gmail.com> wrote:
> The "statin hypothesis" is that treating cholesterol above a certain level
> with statins is medically recommended.

### No, this is not the statin hypothesis.

> That level has been consistently lowered over the years. The fact that
> statins lower all-cause mortality in specified populations doesn't "prove"
> the statin hypothesis unless the specified population is "everyone with
> cholesterol level over N", which doesn't seem to be the case.
>From a quick google, it appears the population helped is those with
> coronary artery disease.

### Statins lower all-cause mortality in primary prevention, which pretty
much means "everyone with cholesterol level over N", the exact level
depending on the study:

PMID 27043432
PMID 26864092

> Lowering mortality is great, but how much is it lowered and at what cost?

### See references above. Pennies a day.

> Statins aren't without side effects.

### For most users they are.

If you have myalgia or liver damage, obviously don't use statins.
Otherwise, use statins according to guidelines.

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