[ExI] book

Rafal Smigrodzki rafal.smigrodzki at gmail.com
Mon Sep 5 01:50:10 UTC 2016


On Wed, Aug 17, 2016 at 11:27 AM, Dave Sill <sparge at gmail.com> wrote:
>
>
> The "statin hypothesis" is that treating cholesterol above a certain level
> with statins is medically recommended.
>

### No, this is not the statin hypothesis.
 ---------------------

> That level has been consistently lowered over the years. The fact that
> statins lower all-cause mortality in specified populations doesn't "prove"
> the statin hypothesis unless the specified population is "everyone with
> cholesterol level over N", which doesn't seem to be the case.
>
>From a quick google, it appears the population helped is those with
non-obstructive
> coronary artery disease.
>

### Statins lower all-cause mortality in primary prevention, which pretty
much means "everyone with cholesterol level over N", the exact level
depending on the study:

PMID 27043432
<http://www-ncbi-nlm-nih-gov.proxy.library.vcu.edu/pubmed/27043432>
PMID 26864092
<http://www-ncbi-nlm-nih-gov.proxy.library.vcu.edu/pubmed/26864092>
---------------


> Lowering mortality is great, but how much is it lowered and at what cost?
>

### See references above. Pennies a day.
---------------


> Statins aren't without side effects.
>

### For most users they are.

If you have myalgia or liver damage, obviously don't use statins.
Otherwise, use statins according to guidelines.

Rafał
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://lists.extropy.org/pipermail/extropy-chat/attachments/20160904/06aa8604/attachment.html>


More information about the extropy-chat mailing list