[ExI] Autophagy and Aging
avant at sollegro.com
Sat May 4 01:57:08 UTC 2019
For those of you who might have missed it, the 2016 Nobel Prize in
Medicine or Physiology went to Yoshinori Ohsumi for his work
elucidating the mechanisms of autophagy. Briefly, autophagy is when
cells are induced to digest their own damaged proteins to salvage
amino acids for other purposes. It is evolutionarily a highly
conserved process that we share with creatures as primitive as yeast.
Here is a very good open access article in Cell about the process of
autophagy and its role in health and disease:
What I have learned is that when you don't eat for at least 16 hours
or so, your body starts the process of autophagy where it digests worn
out and damaged proteins in order to use the amino acids to synthesize
new fully-functional proteins as well as synthesize glucose for your
brain and your liver through the process of gluconeogenesis. Autophagy
peaks between 24 and 48 hours and then declines to a slow and steady
rate, once your body switches to burning your fat stores to obtain
ketones to fuel your brain instead of glucose from amino acids.
The upshot of this is that short fasts of between 24 and 48 hours do
wonders for your health potentially reversing some of the effects of
aging caused by the build up of worn out proteins and organelles in
cells. I have been experimenting on myself by eating every other day
both to both lose weight and to induce autophagy and I can't help but
notice beneficial effects. My mood is improved, I feel sharper and
more energetic with a general sense of well-being. Moreover, I have
lost about 15 pounds in three weeks this way.
On my fasting days, I try to get by on black morning coffee and a
multivitamin and then water alone for the rest of the day. But if I
get too hungry, then I eat a tablespoon of pure fat like butter, olive
oil, or coconut oil. But I avoid eating any carbs or protein for the
On my eating days, I pretty much eat anything I feel like eating,
For those of you who don't need to lose weight, I would just eat as
much pure fat as you can stomach but nothing else, on one or two days
a week so you can induce autophagy without losing any weight. Then
make it a point to eat extra protein after the one or two fat only
days are finished so you don't lose muscle mass.
Anyways, water only fasting every other day is working for me so I
thought I would share.
More information about the extropy-chat