[ExI] good news/bad news

[Dylan Distasio]

I saw this paper yesterday, and speculate that a combination of iron
chelation agents and blood transfusions should be effective if this turns
out to be true.

On Thu, Apr 9, 2020 at 9:24 AM Dave Sill via extropy-chat <
extropy-chat at lists.extropy.org> wrote:

> On Thu, Apr 9, 2020 at 8:58 AM William Flynn Wallace via extropy-chat <
> extropy-chat at lists.extropy.org> wrote:
>
>> In our paper this morning is a report of a local anesthesiologist
>> building a ventilator for less than $100 from parts available at Lowe's or
>> Home Depot.  They can be made in under an hour and more than 100 have been
>> made.  Parts include garden hose and a lamp timer.  The MS medical center
>> is applying for emergency use permission.
>>
>
> Ventilators aren't very effective. This preprint might explain why:
>
>
> https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surface_Glycoprotein_Inhibit_Heme_Metabolism_by_Binding_to_Porphyrin/11938173/6
>
> "The novel coronavirus pneumonia (COVID-19) is an infectious acute
> respiratory infection caused by the novel coronavirus. The virus is a
> positive-strand RNA virus with high homology to bat coronavirus. In this
> study, conserved domain analysis, homology modeling, and molecular docking
> were used to compare the biological roles of certain proteins of the novel
> coronavirus. The results showed the ORF8 and surface glycoprotein could
> bind to the porphyrin, respectively. At the same time, orf1ab, ORF10, and
> ORF3a proteins could coordinate attack the heme on the 1-beta chain of
> hemoglobin to dissociate the iron to form the porphyrin. The attack will
> cause less and less hemoglobin that can carry oxygen and carbon dioxide.
> The lung cells have extremely intense poisoning and inflammatory due to the
> inability to exchange carbon dioxide and oxygen frequently, which
> eventually results in ground-glass-like lung images. The mechanism also
> interfered with the normal heme anabolic pathway of the human body, is
> expected to result in human disease. According to the validation analysis
> of these finds, chloroquine could prevent orf1ab, ORF3a, and ORF10 to
> attack the heme to form the porphyrin, and inhibit the binding of ORF8 and
> surface glycoproteins to porphyrins to a certain extent, effectively
> relieve the symptoms of respiratory distress. Since the ability of
> chloroquine to inhibit structural proteins is not particularly obvious, the
> therapeutic effect on different people may be different. Favipiravir could
> inhibit the envelope protein and ORF7a protein bind to porphyrin, prevent
> the virus from entering host cells, and catching free porphyrins. This
> paper is only for academic discussion, the correctness needs to be
> confirmed by other laboratories. Due to the side effects and allergic
> reactions of drugs such as chloroquine, please consult a qualified doctor
> for treatment details, and do not take the medicine yourself."
>
> Basically, they think the virus binds to hemoglobin and doesn't unbind. So
> forcing oxygen into the lungs is of limited use since the blood's capacity
> to carry oxygen is diminished.
>
> -Dave
>
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