[ExI] link

[Stuart LaForge]

Quoting Bill W:

> Take vitamin E.  Don't bother.  Take glucosamine.  Don't bother.  Who
> knows?  It might matter, so I will.   bill w
>
> https://www.studyfinds.org/glucosamine-reduce-death-risk-as-much-as-exercise/

The glucosamine effect seems legit since they are getting reproducible  
results from studies on both sides of the Atlantic. If glucosamine can  
increase LDL particle size in the bloodstream like the authors  
suggest, then that is pretty nifty because there is correlation  
between LDL particle size and longevity. Here is the actual  
peer-reviewed article, if you want to weigh the numbers yourself:

https://www.jabfm.org/content/jabfp/33/6/842.full.pdf

---------------------------------------------------------------------------------
Abstract
Background: Limited previous studies in the United Kingdom or a single  
US state have demonstrated
an association between intake of glucosamine/chondroitin and  
mortality. This study sought to investigate the association between  
regular consumption of glucosamine/chondroitin and overall and  
cardiovascular (CVD) mortality in a national sample of US adults.
Methods: Combined data from 16,686 participants in National Health and  
Nutrition Examination
Survey 1999 to 2010, merged with the 2015 Public-use Linked Mortality  
File. Cox proportional hazards
models were conducted for both CVD and all-cause mortality.
Results: In the study sample, there were 658 (3.94%) participants who  
had been taking glucosamine/
chondroitin for a year or longer. During followup (median, 107  
months), there were 3366 total deaths
(20.17%); 674 (20.02%) were due to CVD. Respondents taking  
glucosamine/chondroitin were less likely to
have CVD mortality (hazard ratio [HR] = 0.51; 95% CI, 0.28-0.92).  
After controlling for age, use was associated with a 39% reduction in  
all-cause (HR = 0.61; 95% CI, 0.49–0.77) and 65% reduction (HR = 0.35;  
95%
CI, 0.20–0.61) in CVD mortality. Multivariable-adjusted HR showed that  
the association was maintained after adjustment for age, sex, race,  
education, smoking status, and physical activity (all-cause mortality,
HR = 0.73; 95% CI, 0.57–0.93; CVD mortality, HR = 0.42; 95% CI, 0.23–0.75).
Conclusions: Regular intake of glucosamine/chondroitin is associated  
with lower all-cause and
CVD mortality in a national US cohort and the findings are consistent  
with previous studies in other
populations. Prospective studies to confirm the link may be warranted.  
( J Am Board Fam Med
2020;33:842–847.)
------------------------------------------------------------------

Stuart LaForge