<!DOCTYPE html PUBLIC "-//W3C//DTD HTML 4.01 Transitional//EN">
<html>
<head>
<meta content="text/html;charset=ISO-8859-1" http-equiv="Content-Type">
<title></title>
</head>
<body bgcolor="#ffffff" text="#000000">
Actually I have been thinking about this for many years (over 2
decades) and what has to be done is to put the body into<br>
near hibernation state and slow metabolism to a crawl. The introduced
cells have to be able to function at a high<br>
rate even under these conditions and perhaps even have a metabolism
that either stops or self-destructs at<br>
normal body temperatures and metabolism as a failsafe. The body
metabolism over perhaps a month might be equivalent to an hour while
the introduced cells are working at breakneck speed and may be able do
a years work over that month.<br>
<br>
These cells would have to metabolize energy sources that the body would
otherwise consider inert.<br>
The introduced cells should have to be able to carry away, or
metabolize dangerous waste biological products of the<br>
hibernating body as well.<br>
Just think about the creation of several separate secondary
"programmable" armies of specialized minicells.<br>
We use the term nanobot without the slightest clue as to what they
might be or how they would operate so this is quite in line with that
concept.<br>
What we might have to do is provide them with an environment where they
can work efficiently <br>
and with undue interference from normal body processes.<br>
<br>
Indeed it might take interaction with a number of supervisory systems
ranging from MRI type scanners , and AI complexity<br>
oversight to move this process from start to finish without killing the
customer.<br>
<br>
A new stem cell population would need to be grown beforehand, perhaps
in a controlled way sequestered in the body<br>
much like an encapsulated tumor or embryo and harvested prior to the
regerarative procedure.<br>
And the leuekemia analogy is a good one, perhaps we shall find
deliberate creation of a cancerous stem cell<br>
population the best way to create a large population of embyonic case
type cells to infuse back. Remember, cancer cells<br>
can slither around and take root in all manner of places in the body
quite efficiently. The trick is to be able to turn on and off this<br>
mechanism on demand. <br>
<br>
I think that with the convergence of technologies at a singularity
level with AI level computational capacity there is hope to<br>
create this level of sophistication in the mangement of biological
systems.<br>
<br>
I did not say that this would be easy. <br>
<br>
Just remember that what we consider normal in terms of computer chips
and their functions would have been<br>
considered magic or witchcraft and idle fantasy as little as 100 years
ago.<br>
<br>
Morris.<br>
<br>
<br>
<br>
<br>
Brett Paatsch wrote:
<blockquote cite="mid013601c5e5db$d50bb540$8998e03c@homepc" type="cite">
<title></title>
<meta http-equiv="Content-Type" content="text/html;charset=ISO-8859-1">
<meta content="MSHTML 6.00.2900.2769" name="GENERATOR">
<style></style>
<blockquote
style="border-left: 2px solid rgb(0, 0, 0); padding-right: 0px; padding-left: 5px; margin-left: 5px; margin-right: 0px;">
<div
style="background: rgb(228, 228, 228) none repeat scroll 0%; -moz-background-clip: initial; -moz-background-origin: initial; -moz-background-inline-policy: initial; font-family: arial; font-style: normal; font-variant: normal; font-weight: normal; font-size: 10pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"><b>From:</b>
<a title="megao@sasktel.net" href="mailto:megao@sasktel.net">Lifespan
Pharma Inc/ MFJ-CTO</a> </div>
<div
style="font-family: arial; font-style: normal; font-variant: normal; font-weight: normal; font-size: 10pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"><b>To:</b>
<a title="extropy-chat@lists.extropy.org"
href="mailto:extropy-chat@lists.extropy.org">ExI chat list</a> </div>
<div
style="font-family: arial; font-style: normal; font-variant: normal; font-weight: normal; font-size: 10pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"><b>Sent:</b>
Thursday, November 10, 2005 6:50 PM</div>
<div
style="font-family: arial; font-style: normal; font-variant: normal; font-weight: normal; font-size: 10pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"><b>Subject:</b>
[extropy-chat] Aging as a function of bone marrow degradation</div>
<div><br>
</div>
<div>But that's the challenge, to switch every body cell on as a
totipotent cancer cell similtaneously, slow down the metabolism so<br>
none divides, circulate a swarm of autoimmune cells to tag defective
cells for future destruction, reset all the switches<br>
, crank up the metabolism and send in the scavenger cells to wack out
the burned out cells and infuse a new batch of stem cells<br>
into every tissue to rebuild tissues. A massive order, but like with
"Doctor Who" it is steady state-evolution which will replace<br>
natural selection by death or illness. The trick is to maintain the
memory and consciousness of the brain through this<br>
housecleaning operation.<br>
</div>
</blockquote>
<div><font face="Arial" size="2">"</font><font face="Arial" size="2">Every
body cell" would give you a base set of around 100 trillion cells.</font></div>
<div> </div>
<div><font face="Arial" size="2">Lets say you wanted to switch every
body cell to a cancer cell (I don't think</font></div>
<div><font face="Arial" size="2">that </font><font face="Arial"
size="2">even makes sense - but lets say), how </font><font
face="Arial" size="2">would you do it? With what </font></div>
<div><font face="Arial" size="2">hormone or molecule? Or are you
thinking nanobots? </font></div>
<div> </div>
<div><font face="Arial" size="2">How would you slow down metabolism
so no cells divide? Metabolism </font></div>
<div><font face="Arial" size="2">works in </font><font face="Arial"
size="2">such a way that when cells stop getting fed (glucose levels in</font></div>
<div><font face="Arial" size="2">blood are low) some </font><font
face="Arial" size="2">cells (in the liver say) go into glucose or
ketone</font></div>
<div><font face="Arial" size="2">bodies </font><font face="Arial"
size="2">from fat </font><font face="Arial" size="2">production
specifically to fed other </font><font face="Arial" size="2">cells (like
brain </font><font face="Arial" size="2">cells)</font></div>
<div><font face="Arial" size="2">so that they </font><font
face="Arial" size="2">wont </font><font face="Arial" size="2">die
when there is no dietary glucose </font><font face="Arial" size="2">available.
</font></div>
<div><font face="Arial" size="2">Or by slowing down metabolism did
you mean cryonics?</font> </div>
<div> </div>
<div><font face="Arial" size="2">Where do your autoimmune cells that
are to do the tagging to </font><font face="Arial" size="2">come</font></div>
<div><font face="Arial" size="2">from themselves (you stopped cell
division -somehow- remember)? </font><font face="Arial" size="2">What</font></div>
<div><font face="Arial" size="2">cell </font><font face="Arial"
size="2">markers are they to </font><font face="Arial" size="2">zero
in on? If you've made *</font><font face="Arial" size="2">every* cell
cancerous</font></div>
<div><font face="Arial" size="2">how many macrophage/eater cells are
you going to have to have ? How do</font></div>
<div><font face="Arial" size="2">you imagine they'll fit
geometrically in the body made of other cells?</font></div>
<div> </div>
<div><font face="Arial" size="2">Are your scavenger cells "carrying"
the new batch of stem cells? How</font></div>
<div><font face="Arial" size="2">are they </font><font face="Arial"
size="2">getting through the blood brain barrier?</font></div>
<div> </div>
<div><font face="Arial" size="2">I am not even slightly an expert in
this area but I think I know enough </font></div>
<div><font face="Arial" size="2">to recognize </font><font
face="Arial" size="2">that what you have said above doesn't make any
biological</font></div>
<div><font face="Arial" size="2">sense. </font></div>
<div> </div>
<div><font face="Arial" size="2">I mean no offense but it seems like
you might be repeating something</font></div>
<div><font face="Arial" size="2">that you have heard someone else say
which didn't make sense but</font></div>
<div><font face="Arial" size="2">which you didn't understand well
enough to realise that it didn't make</font></div>
<div><font face="Arial" size="2">sense. </font></div>
<div> </div>
<div><font face="Arial" size="2">Brett Paatsch</font></div>
</blockquote>
<br>
</body>
</html>