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<DIV
style="BACKGROUND: #e4e4e4; FONT: 10pt arial; font-color: black"><B>From:</B>
<A title=megao@sasktel.net href="mailto:megao@sasktel.net">Lifespan Pharma
Inc/ MFJ-CTO</A> </DIV>
<DIV style="FONT: 10pt arial"><B>To:</B> <A
title=extropy-chat@lists.extropy.org
href="mailto:extropy-chat@lists.extropy.org">ExI chat list</A> </DIV>
<DIV style="FONT: 10pt arial"><B>Sent:</B> Thursday, November 10, 2005 6:50
PM</DIV>
<DIV style="FONT: 10pt arial"><B>Subject:</B> [extropy-chat] Aging as a
function of bone marrow degradation</DIV>
<DIV><FONT face=Arial size=2></FONT><FONT face=Arial size=2></FONT><FONT
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<DIV>But that's the challenge, to switch every body cell on as a totipotent
cancer cell similtaneously, slow down the metabolism so<BR>none divides,
circulate a swarm of autoimmune cells to tag defective cells for future
destruction, reset all the switches<BR>, crank up the metabolism and send in
the scavenger cells to wack out the burned out cells and infuse a new batch of
stem cells<BR>into every tissue to rebuild tissues. A massive order, but
like with "Doctor Who" it is steady state-evolution which will
replace<BR>natural selection by death or illness. The trick is to
maintain the memory and consciousness of the brain through
this<BR>housecleaning operation.<BR></DIV></BLOCKQUOTE>
<DIV><FONT face=Arial size=2>"</FONT><FONT face=Arial size=2>Every body cell"
would give you a base set of around 100 trillion cells.</FONT></DIV>
<DIV><FONT face=Arial size=2></FONT> </DIV>
<DIV><FONT face=Arial size=2>Lets say you wanted to switch every
body cell to a cancer cell (I don't think</FONT></DIV>
<DIV><FONT face=Arial size=2>that </FONT><FONT face=Arial size=2>even makes
sense - but lets say), how </FONT><FONT face=Arial size=2>would you do
it? With what </FONT></DIV>
<DIV><FONT face=Arial size=2>hormone or molecule? Or are you thinking
nanobots? </FONT></DIV>
<DIV><FONT face=Arial size=2></FONT> </DIV>
<DIV><FONT face=Arial size=2>How would you slow down metabolism so no cells
divide? Metabolism </FONT></DIV>
<DIV><FONT face=Arial size=2>works in </FONT><FONT face=Arial size=2>such a way
that when cells stop getting fed (glucose levels in</FONT></DIV>
<DIV><FONT face=Arial size=2>blood are low) some </FONT><FONT face=Arial
size=2>cells (in the liver say) go into glucose or ketone</FONT></DIV>
<DIV><FONT face=Arial size=2>bodies </FONT><FONT face=Arial size=2>from fat
</FONT><FONT face=Arial size=2>production specifically to fed other
</FONT><FONT face=Arial size=2>cells (like brain </FONT><FONT face=Arial
size=2>cells)</FONT></DIV>
<DIV><FONT face=Arial size=2>so that they </FONT><FONT face=Arial size=2>wont
</FONT><FONT face=Arial size=2>die when there is no dietary glucose </FONT><FONT
face=Arial size=2>available. </FONT></DIV>
<DIV><FONT face=Arial size=2>Or by slowing down metabolism did you mean
cryonics?</FONT> </DIV>
<DIV><FONT face=Arial size=2></FONT> </DIV>
<DIV><FONT face=Arial size=2>Where do your autoimmune cells that are to do
the tagging to </FONT><FONT face=Arial size=2>come</FONT></DIV>
<DIV><FONT face=Arial size=2>from themselves (you stopped cell division
-somehow- remember)? </FONT><FONT face=Arial size=2>What</FONT></DIV>
<DIV><FONT face=Arial size=2>cell </FONT><FONT face=Arial size=2>markers are
they to </FONT><FONT face=Arial size=2>zero in on? If you've made
*</FONT><FONT face=Arial size=2>every* cell cancerous</FONT></DIV>
<DIV><FONT face=Arial size=2>how many macrophage/eater cells are you going to
have to have ? How do</FONT></DIV>
<DIV><FONT face=Arial size=2>you imagine they'll fit geometrically in the body
made of other cells?</FONT></DIV>
<DIV><FONT face=Arial size=2></FONT> </DIV>
<DIV><FONT face=Arial size=2>Are your scavenger cells "carrying" the new batch
of stem cells? How</FONT></DIV>
<DIV><FONT face=Arial size=2>are they </FONT><FONT face=Arial size=2>getting
through the blood brain barrier?</FONT></DIV>
<DIV><FONT face=Arial size=2></FONT> </DIV>
<DIV><FONT face=Arial size=2>I am not even slightly an expert in this area but I
think I know enough </FONT></DIV>
<DIV><FONT face=Arial size=2>to recognize </FONT><FONT face=Arial size=2>that
what you have said above doesn't make any biological</FONT></DIV>
<DIV><FONT face=Arial size=2>sense. </FONT></DIV>
<DIV><FONT face=Arial size=2></FONT> </DIV>
<DIV><FONT face=Arial size=2>I mean no offense but it seems like you might be
repeating something</FONT></DIV>
<DIV><FONT face=Arial size=2>that you have heard someone else say
which didn't make sense but</FONT></DIV>
<DIV><FONT face=Arial size=2>which you didn't understand well enough to realise
that it didn't make</FONT></DIV>
<DIV><FONT face=Arial size=2>sense. </FONT></DIV>
<DIV><FONT face=Arial size=2></FONT> </DIV>
<DIV><FONT face=Arial size=2>Brett Paatsch</FONT></DIV></BODY></HTML>