<br>The thing to remember about viruses is that they are very small and if one can control their numbers they are not a problem. So this allows people to live with diseases like TB or Hepatitis for extended periods. It helps if you have access to the technlogy and a physician (so money is a +) which allows you to stay on the leading edge of understanding the virus and its therapies.
<br><br>HIV is a relatively simple virus (only a few genes) and suffers from the benefit / handicap that its genome copying gene/protein (the reverse transcriptase) is relatively sloppy (making inaccurate copies). So this (a) means that the virus can't be *too* productive since many of the copies it makes may not work; and (b) the copies it can make will vary enough that they may develop resistance to the drugs being used to treat the disease.
<br><br>HIV also infects cells in the body (white blood cells) which are designed to be able to replace themselves at a relatively high rate. So if the virus kills the cells, or the other cells in the immune system kill the cells containing the virus, they can be replaced (if one knocks the virus down to low enough levels).
<br><br>The problems with early HIV treatments is that they used only a single drug so it was relatively easy for the virus to develop mutants that that drug was ineffective against. With the development of the so-called "triple cocktail" approach three drugs are used which target different vulnerabilities in the virus reproduction pathways. So to work around the drugs the virus has to develop three mutations which becomes much more difficult. As there are multiple drugs with somewhat different effects and we have sufficient information now about which mutations are bypassing specific drugs physicians can monitor how a viral load is mutating and change drug therapies in response to that.
<br><br>So I suspect Magic simply has access to physicians and labs on the cutting edge of the knowledge curve and might be able to gain access to the newest drugs sooner than knowledge about them is made generally available. I worked in the HIV lab at the Univ. of Washington for a summer in the early '90s - this is a *very* specialized branch of medicine and to get the best quality care you need to get physicians who go to the HIV conferences, have access to the best lab facilities, know what drugs are being developed, are aware of how the virus is evolving (from the perspective of individual patients as well as in cities, countries & world regions), etc.. Fortunately many patients have the self-interest to learn all that they can about the disease (and even go read the journal articles if they have the interest) -- PubMed is a significant public resource now (as are Wikipedia, many open access journals and the non-physician AIDS therapeutic networks).
<br><br>There is also hope on the horizon that a couple of more targets may develop for the virus (so a triple cocktail may turn into a quintuple cocktail).<br><br>Some simple questions for your physician:<br>a) Do they know how they will change your drug therapy in response to the development of resistance by the virus? (
I.e. if the viral load increases.).<br>b) Do they know what mutations make the virus resistant to the drugs you are currently taking? (Specific mutations in specific genes lead to resistance to specific drugs.)<br>c) Have they sequenced (or when do they plan to sequence) your current virus?
<br><br>Most physicians operate at the level of (a) and the general response is that if the standard drugs aren't working to change the recipe. The people who really know what they are doing know which mutations cause the drugs to lose efficacy (b) and know whether or not *you* have them (c).
<br><br>Right now there is no "cure" for HIV (in fact this is probably true for many viruses) -- there a continual effort however to keep confining it to ever smaller boxes (which make it both difficult to transmit and may eventually give your immune system the upper hand with respect to eliminating the cells which harbor it).
<br><br>Eventually there will be nanorobots which will be able to wander through your body identify HIV viruses which are behaving badly (trying to infect other cells) and rip them to shreds -- we are still a few decades away from that however.
<br><br>Robert<br><br>P.S. If you do not have a strong medical background I would strongly urge you spend some time with Wikipedia, a medical dictionary for terms not in Wikipedia and then perhaps HIV review articles from PubMed (go to PubMed and query on "HIV AND review"). I believe that approach will rapidly get you up to speed.
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