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<DIV><FONT face=Arial size=2>Four days a week, I'm quite impressed you haven't
been sectioned by now.</FONT></DIV>
<DIV><FONT face=Arial size=2></FONT> </DIV>
<DIV><FONT face=Arial size=2>Magic mushroom tend to require quite a lot of
recovery time afterwards to reach full potential again, most people leave it
weeks before they eat anymore. I've not tried LSD, so I'm not sure just how long
the recovery time on that is.</FONT></DIV>
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<DIV><FONT face=Arial size=2>One of the first things Hoffmann noted about LSD
was that the day after he woke up feeling particularly sensitive to the
world.</FONT></DIV>
<DIV><FONT face=Arial size=2></FONT> </DIV>
<DIV><FONT face=Arial size=2>This, combined with knowing that these molecules
are metabolised out of the synapses and that immediately afterwards their
potential for effect decreases suggests to me that they trigger an increase in
the 'esterase metabolic pathways in the synapses. E.g. you take LSD, your body
senses that it's become lodged in the post-synaptic boutons (atropine does this
I believe, and is used to treat nerve agent exposure by 'clogging' the
synapses to prevent spasmodic firing) and increases the levels of esterase to
break it down. Afterwards, those level likely remain elevated for a while,
allowing the synapse to carry a higher bandwidth of signals, allowing for a
greater level of sensitivity.</FONT></DIV>
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<DIV><FONT face=Arial size=2>This is all pure speculation, but it seems like the
most likely way these effects would emerge to me.</FONT></DIV>
<DIV><FONT face=Arial size=2></FONT> </DIV>
<DIV><FONT face=Arial size=2>I've noticed something similar after trying
psilocybin mushrooms. Just out of interest, do you get a headache the morning
after with LSD?</FONT></DIV>
<DIV><FONT face=Arial size=2></FONT> </DIV>
<DIV><FONT face=Arial size=2>I've often wondered about the possibility of mixing
psychoactives to achieve greater effects. As you pointed out, sooner or later
you reach a peak that's difficult to go beyond due to pathways
being saturated / metabolism wiping out the active material etc. However,
if multiple actives where used, one might expect the experience to be orders of
magnitude more diverse - mescaline, psilocybin and salvinorin say,
which all work on different receptor sites (off the top of my head, I think
it's mainly... muscarine, serotonin and kappa opoid respectively). And finish it
off with a monoamine oxidase inhibitor.</FONT></DIV>
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<DIV><FONT face=Arial size=2>Never tried Heroin. I tend not to believe too much
of the anti-drugs stuff I read but there certainly does seem to be a correlation
between Heroin and bin diving.</FONT></DIV>
<DIV><FONT face=Arial size=2></FONT> </DIV>
<DIV><FONT face=Arial size=2>In light of Bill's note, I live in the UK, where
magic mushrooms were legal fodder until recently.</FONT></DIV>
<DIV><FONT face=Arial size=2></FONT> </DIV>
<DIV><FONT face=Arial size=2>John</FONT></DIV></BODY></HTML>
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