<HTML><BODY style="word-wrap: break-word; -khtml-nbsp-mode: space; -khtml-line-break: after-white-space; "><DIV><BLOCKQUOTE type="cite"><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 41px; text-indent: -41px; font: normal normal normal 12px/normal Helvetica; color: rgb(0, 0, 0); min-height: 14px; "><BR></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 41px; text-indent: -41px; "><FONT face="Helvetica" size="3" color="#000000" style="font: 12.0px Helvetica; color: #000000"><B>From: </B></FONT><FONT face="Helvetica" size="3" style="font: 12.0px Helvetica">BillK <<A href="mailto:pharos@gmail.com">pharos@gmail.com</A>></FONT></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 40px; text-indent: -40px; "><FONT face="Helvetica" size="3" color="#000000" style="font: 12.0px Helvetica; color: #000000"><B>Date: </B></FONT><FONT face="Helvetica" size="3" style="font: 12.0px Helvetica">June 15, 2007 1:13:17 AM MST</FONT></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 25px; text-indent: -25px; "><FONT face="Helvetica" size="3" color="#000000" style="font: 12.0px Helvetica; color: #000000"><B>To: </B></FONT><FONT face="Helvetica" size="3" style="font: 12.0px Helvetica">"ExI chat list" <<A href="mailto:extropy-chat@lists.extropy.org">extropy-chat@lists.extropy.org</A>></FONT></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 55px; text-indent: -55px; "><FONT face="Helvetica" size="3" color="#000000" style="font: 12.0px Helvetica; color: #000000"><B>Subject: </B></FONT><FONT face="Helvetica" size="3" style="font: 12.0px Helvetica"><B>Re: [ExI] does the pedal meet the medal?</B></FONT></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 64px; text-indent: -64px; "><FONT face="Helvetica" size="3" color="#000000" style="font: 12.0px Helvetica; color: #000000"><B>Reply-To: </B></FONT><FONT face="Helvetica" size="3" style="font: 12.0px Helvetica">ExI chat list <<A href="mailto:extropy-chat@lists.extropy.org">extropy-chat@lists.extropy.org</A>></FONT></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; min-height: 14px; "><BR></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; min-height: 14px; "><BR></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">On 6/15/07, Samantha Atkins wrote:</DIV> <BR><BLOCKQUOTE type="cite"><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">Is it possible to get some of the more promising cognitive drugs out</DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">there today like CX717?<SPAN class="Apple-converted-space"> </SPAN>Yes I realize it is officially early in the</DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">official cycle.<SPAN class="Apple-converted-space"> </SPAN>But by the time the "official" cycle is done and it</DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">is approved "officially" for strictly non-enhancement use only as per</DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">usual I will have experienced several years of lower memory and</DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">concentration that I could otherwise have along with many tens of</DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">millions of other boomers. <SPAN class="Apple-converted-space"> </SPAN>What can be done?<SPAN class="Apple-converted-space"> </SPAN>Not 10 years from</DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">now if then but now or as close to it as possible?<SPAN class="Apple-converted-space"> </SPAN>Can we do</DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">nothing but talk and hope to get enough influence some day to</DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">influence the "official line"?<SPAN class="Apple-converted-space"> </SPAN>I don't think we will ever get there.</DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">Not in this country where even something as no-brainer as stem cell R</DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">& D (or even R only) has to battle like mad. <SPAN class="Apple-converted-space"> </SPAN>So what is to be done?</DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; min-height: 14px; "><BR></DIV> <BR></BLOCKQUOTE><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; min-height: 14px; "><BR></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">Natural stuff is probably easier to obtain.</DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">You can try ingesting 'natural' stuff like snake venom, cyanide,</DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">globefish poison, or the nightshade family, etc.</DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; min-height: 14px; "><BR></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">What do you mean 'It's poison!'. Only in certain dosages, and they</DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">could be combined with other substances as well. Where's your sense of</DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">adventure?</DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; min-height: 14px; "><BR></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">Just because something has a technical name like CX717 doesn't mean</DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">it's not poison. That's the point of long term testing.</DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; min-height: 14px; "><BR></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; min-height: 14px; "><BR></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">BillK</DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; min-height: 14px; "><BR></DIV></BLOCKQUOTE>In my non expert opinion ampakines work by means of their toxic effect on re-uptake receptors. I believe this interferes with the brain's self regulation. Along with enhanced learning and memory, I prefer to include better self regulation. I don't know what Ray Kurzweil takes, but I very seldom indulge in stimulants or depressants. I prefer non toxic nutropics. My favorites are L-tyrosine and DMAE (liquid).<BR></DIV><DIV><BR class="khtml-block-placeholder"></DIV><DIV>Regarding what to do about restricted access to chemicals we like: Some say greater risks afford greater rewards. I sometimes consider it ethical to bypass systems that represent a liability. I suppose conflict can be fun. On the other hand what if something as simple as sunlight on my retinas to shut off melatonin production does the trick? -- Thomas</DIV></BODY></HTML>