<p class="MsoNormal">03-Healthy<span style=""> </span>Biology </p>
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<p class="MsoNormal">All living things<span style="">
</span>have metabolism, metabolism continually causes damage , damage
eventually causes pathology , pathology is disease, and leads to<span style=""> </span>aging then death.<span style=""> </span>Mother nature made biology so complicated<span style=""> </span>so every generation<span style=""> </span>would have no choice but to grow up,
reproduce, nurture offspring and then get dead as fast as possible to make room
for the next go round.</p>
<p class="MsoNormal"> </p>
<p class="MsoNormal">"You know what dad, We think there's hope for you yet.<span style=""> </span>Let's see you weasel out of this one".</p>
<p class="MsoNormal">"To do justice to the topic this time, the kids are going to
see dad sweat , by golly", says I.</p>
<p class="MsoNormal"> </p>
<p class="MsoNormal">Metabolism is the incredibly complex network of molecular
and cellular processes that keep us alive. Gerontologists study metabolism.
Pathology is the network of molecular processes that kill us. Geriatricians
study disease pathology.<span style=""> </span>A whole<span style=""> </span>new breed of anti-aging specialists study
and treat<span style=""> </span>the missing link, damage.<span style=""> </span><a href="http://www.msnbc.msn.com/id/23358964/">http://www.msnbc.msn.com/id/23358964/</a><span style=""> </span>documents how some<span style=""> </span>simple regenerative measures are now part of
integrative (combining of all possible options into a carefully planned
package) medicine.</p>
<p class="MsoNormal"> </p>
<p class="MsoNormal">You can turn an old car into a vintage classic car by
assessing the condition then systematically repairing the old damage , then
continue watching<span style=""> </span>for new damage and
fix<span style=""> </span>that too.<span style=""> </span>Why can't you do the same with people?<span style=""> </span>That's the "engineering approach" proposed by Dr Aubrey de Grey,
founder of the Methusalah Foundation., Cambridge , UK.<span style=""> </span>He has raised 10 million dollars of funding
in the last 2 years and awards funding for research towards creating a
replicatable animal model,<span style=""> </span>the
Rejuvenated Robust "Methusalah" Mouse (MM).<span style="">
</span>Simply put take a mouse as old as a 55 year old human (in mouse years)
and give it<span style=""> </span>3 times its remaining life
expectancy , all in good health..<span style=""> </span>If
you use these same age retarding techniques on people you should<span style=""> </span>halve the rate of damage and<span style=""> </span>add 30 extra healthy years to the 30
expected for a 55 year old and raise total healthspan by 20% overall.<span style=""> </span></p>
<p class="MsoNormal"> </p>
<p class="MsoNormal">Aubrey sees damage repair as the critical control points
that reduce the metabolic hazards to an acceptable level and manage the risk of
diminished quality of the finished product, lifespan..<span style=""> </span>Aubrey has segmented the damage into 7
categories: junk inside cells, junk outside cells, too few cells, too many
cells, chromosome mutations, mitochondria (energy producing intracellular
organelles) mutations and protein crosslinks.<span style="">
</span>For each category there is a proposed repair strategy.<span style=""> </span>The sum of these strategies is termed
"engineered negligible senescence" (SENS)[<span style="">
</span><a href="http://richardjschueler.com/gallery2/main.php?g2_itemId=56847">http://richardjschueler.com/gallery2/main.php?g2_itemId=56847</a><span style=""> </span>] .<span style="">
</span>Later in this series I will discuss the safety and efficacy of specific
current therapies as they relate to the "seven deadly sins of<span style=""> </span>metabolism".<span style=""> </span>These interventions are at various stages of research,
development and clinical<span style=""> </span>and<span style=""> </span>every day commercial<span style=""> </span>application.<span style=""> </span>Aubrey states that you don't have to repair all the damage at
once.<span style=""> </span>If you start at the "biological
age" of 55 and select the most critical<span style="">
</span>areas and fix<span style=""> </span>HALF THE
DAMAGE<span style=""> </span>you should double the total
healthspan and raise the remaining healthspan<span style="">
</span>5 times.<span style=""> </span>The goal for a
commercial regenerative medicine industry would be to reduce the remaining
damage each time therapy is undertaken and implement increasingly more
effective repair.<span style=""> </span>Eventually repair
happens faster than new damage occurs. </p>
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<p class="MsoNormal">FYI-Watch the<span style=""> </span>BBC TV
series " How to Build a Human 4of4 - Forever Young (60 minutes)<span style=""> </span>1/6<span style=""> </span><a href="http://www.youtube.com/watch?v=T7ZAhdSidzk">http://www.youtube.com/watch?v=T7ZAhdSidzk</a><span style=""> </span></p>
<p class="MsoNormal">2/6<span style=""> </span><a href="http://www.youtube.com/watch?v=necHabLN37Q">http://www.youtube.com/watch?v=necHabLN37Q</a></p>
<p class="MsoNormal">3/6<span style=""> </span><a href="http://www.youtube.com/watch?v=1cAIPTPIL7A">http://www.youtube.com/watch?v=1cAIPTPIL7A</a></p>
<p class="MsoNormal">4/6<span style=""> </span><a href="http://www.youtube.com/watch?v=6qqoT1oCEBI">http://www.youtube.com/watch?v=6qqoT1oCEBI</a></p>
<p class="MsoNormal">5/6<span style=""> </span><a href="http://www.youtube.com/watch?v=LObrLpV8ric">http://www.youtube.com/watch?v=LObrLpV8ric</a></p>
<p class="MsoNormal">6/6<span style=""> </span><a href="http://www.youtube.com/watch?v=Pkf23Nn9qX0">http://www.youtube.com/watch?v=Pkf23Nn9qX0</a>
</p>
<p class="MsoNormal"> </p>
<p class="MsoNormal">Aubrey has coined the term "Longevity Escape Velocity" as
the rate at which rejuvenation therapies must improve in order to hope to
outpace the accumulation of damage they cannot currently fully repair. </p>
<p class="MsoNormal">Compare this to manned flight, an insoluble problem since
the dawn of civilization until 1903.<span style="">
</span>Once the<span style=""> </span>Wright Brothers made
the first proven flight, everything was copied and improved upon<span style=""> </span>until today we can fly just about anything
anywhere.<span style=""> </span>For a sneak peek into the
future see : <a href="http://transcurve.net/blog/aaron/10-reasons-you-will-live-to-1000">http://transcurve.net/blog/aaron/10-reasons-you-will-live-to-1000</a>.<span style=""> </span></p>
<p class="MsoNormal"> </p>
<span style="font-size: 12pt; font-family: "Times New Roman";">My next piece will detail the issues surrounding the
bioethics debate about purposefully increasing healthy longevity.<span style=""> </span>You may send your feedback attention
"Pharmer Mo" at <a href="mailto:extropian.pharmer@gmail.com">extropian.pharmer@gmail.com</a></span><br clear="all"><br>