<br>I have been following this topic since the late 1970s <a href="http://www.churchofvirus.org/bbs/index.php?board=54;action=display;threadid=29734">http://www.churchofvirus.org/bbs/index.php?board=54;action=display;threadid=29734</a><br>
<br>All I can say is *wow*.<br><br>Keith<br><br><div class="gmail_quote"><div>
<a href="http://www.dddmag.com/News-Study-Reveals-TA-65-Behavior-050511.aspx?et_cid=1496906&et_rid=45509009&linkid=http%3a%2f%2fwww.dddmag.com%2fNews-Study-Reveals-TA-65-Behavior-050511.aspx" target="_blank">
http://www.dddmag.com/News-Study-Reveals-TA-65-Behavior-050511.aspx?et_cid=1496906&et_rid=45509009&linkid=http%3a%2f%2fwww.dddmag.com%2fNews-Study-Reveals-TA-65-Behavior-050511.aspx</a>
<br>
=====================================================<br>
<font size="5"><b>Study Reveals TA-65 Behavior<br>
</b></font><font size="3">Drug Discovery & Development - May 05,
2011<br><br>
A study, “The Telomerase Activator TA-65 elongates short telomeres and
increases healthspan of adult/old mice without increasing cancer
incidence” describes TA-65’s mechanism of action and organismal
response.<br><br>
Maria Blasco, the head of the National Cancer Research Center in Spain,
and her colleagues demonstrated that TA-65, a naturally occurring
molecule derived from the Astragalus plant, activates the telomerase
enzyme, lengthens critically short telomeres, rescues cells in various
organ systems, and improves healthspan. This activity was not observed in
the control group. <br><br>
The Blasco study states, “TA-65 dietary supplementation in female mice
leads to an improvement of certain health-span indicators including
glucose tolerance, osteoporosis and skin fitness, without significantly
increasing global cancer incidence”.<br><br>
“This study proves the efficacy and legitimacy of TA-65. For
the first time in medical history there is something which has the
potential to effectively lessen and possibly eliminate the crippling
effects of aging decline and degradation caused by insufficient
telomerase and short telomeres,” says Noel Thomas Patton, founder of TA
Sciences,<br><br>
Release Date: April 12, 2011<br>
Source: <a href="http://www.tasciences.com/" target="_blank">T.A. Sciences</a> <br><br>
==============================================================<br>
<a href="http://emediahealth.com/2011/04/23/ta-65-anti-aging-study-shows-health-increase-in-adult-and-old-mice-from-telomerase-lengthening/" target="_blank">
http://emediahealth.com/2011/04/23/ta-65-anti-aging-study-shows-health-increase-in-adult-and-old-mice-from-telomerase-lengthening/</a>
<br>
==============<br>
</font><h1><b>TA-65 Anti-Aging Study Shows Health Increase In Adult and
Old Mice from Telomerase
Lengthening</b></h1><font size="3">
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April 23, 2011</a> by
<a href="http://emediahealth.com/author/alison/" target="_blank">Alison</a><br><br>
The biomedical research journal Aging Cell recently published a study
entitled
<a href="http://onlinelibrary.wiley.com/doi/10.1111/j.1474-9726.2011.00700.x/abstract" target="_blank">
Telomerase activator TA-65 elongates short telomeres and increases health
span of adult/old mice without increasing cancer incidence</a>. The
research adds to the growing evidence that TA-65 can lengthen very short
telomeres and extend the healthy portion of lifespan as indicated by
measurements collected including glucose tolerance, insulin sensitivity,
osteoporosis, and skin condition. The study also examined changes in
cancer rates between the control group and TA-65 supplemented group.
There was a small but statistically insignificant increase in liver
cancer rate, leading to the authors concluding that TA-65 appears to
improve health measures in aging mice without significantly increasing
cancer risk.<br><br>
</font><h3><b>Cancer Researchers Intrigued by TA-65 and Telomerase
Activation</b></h3><font size="3">The research was conducted in Spain by
Maria Blasco of the Spanish National Cancer Research Centre and her
collaborators Bruno Bernardes de Jesus, Kerstin Schneeberger, Elsa Vera,
Agueda Tejera, and Calvin Harley. Cancer researchers are highly
interested in the understanding of telomeres and telomerase because the
majority of cancers appear to multiply rapidly in large part due to the
involvement of the telomerase enzyme that repairs the telomere end caps
on DNA strands, thus allowing unlimited replication of cancer cells. A
major concern with TA-65 and similar compounds such as Geron’s TAT2 is
that they may encourage the growth of cancers. This study shows that the
risk of this appears to be low.<br><br>
Some believe that this is partly due to how TA-65, TAT2, and other
telomerase activators tend to supercharge the immune system and thereby
enable the body to destroy microscopic cancer tumors rapidly before they
get out of control. If so, it is yet another one of the many double-edge
swords of biology in which a single compound that can destroy health can
also immensely benefit health. In biology, context is everything. A
failure to appreciate the overall systemic role of any one biochemical
tends to result in people creating all-good or all-bad
oversimplifications that mislead the public and even many other
scientists. For example, consider how LDL cholesterol has gotten such an
immensely bad rap that it has resulted in the development of numerous
very dangerous drug and diet regimens that actually destroy people’s
health by interrupting chemical pathways in the body that can create
cholesterol. In the process, such treatments deplete the body of CoQ10,
damage mitochondrial health, lower measured levels of necessary sex
hormones, and do little to change the overall risk for cardiovascular
disease. Ironically, some of the treatments can actually increase the
risk of cardiovascular diseases despite lowering the popularly maligned
LDL cholesterol.<br><br>
It’s likely that TA-65, TAT2, and any other telomerase activators are not
going to be either a panacea or a high-priced carcinogenic scam. Aging is
immensely complicated. Frequently it appears that causes of one aging
mechanisms are the effects of other aging mechanisms. In such complex
systems, it is imprudent or even outright irresponsible to oversimplify
the role of any one mechanism such as telomere lengthening. To declare it
as either the “key to reversing aging” or the “key to runaway cancer
growth” is misleading. For starters, telomerase activation may be both at
the same time simply depending upon which cells are using it at the
moment.<br><br>
</font><h3><b>Do Today’s Telomerase Activators Increase
Lifespan?</b></h3><font size="3">There are many questions about just how
bioavailable any of the currently researched telomerase activators truly
are. Additionally, many point out that they seem to function mostly by
increasing telomere length of very short telomeres without affecting the
length of telomeres in most cells. Some question whether there may be
other as yet unknown mechanisms for their actions that could explain
these seemingly conflicting observations. There is still no conclusive
proof that any of the current crop of telomerase activators can extend
lifespan of humans.<br><br>
It’s my personal view that telomere lengthening will one day be regarded
as one major component in workable anti-aging medicine for the masses.
Unfortunately, at present TA-65 is still very expensive and furthermore
the available dosages and observable effects are probably only a fraction
of what is needed to make a huge difference on its own. Even if that
changes markedly, I still believe that many other areas of aging must be
addressed in concert for their to be huge change in health or lifespan of
humans.<br><br>
My particular favorite target today is mitochondrial dysfunction. Poorly
functioning mitochondria are implicated in so many devastating diseases
of aging such as diabetes, Alzheimer’s, Parkinson’s, chronic kidney
disease, chronic liver disease, congestive heart failure, and much more.
There are actually many inexpensive supplements available to target
mitochondrial dysfunction at a reasonable cost and they have
substantially more research backing for effectiveness at improving health
than any telomerase activators do yet.<br><br>
Consider carnitine as an example of one inexpensive but highly effective
supplement for improving mitochondrial health. In recent weeks, I’ve
written several articles on carnitine supplements that are an excellent
first step to improving your mitochondrial health and thereby lowering
risk for diabetes, liver disease, cardiovascular disease, and
neurodegenerative diseases. Carnitine can be used at much lower cost than
more esoteric supplements such as TA-65. A daily dose of 500mg of
carnitine per day can be had in capsule form starting at less than $3 per
month versus $200 per month for the starting dosages of TA-65. Granted,
carnitine is probably not going to directly increase the length of short
telomeres as it is not a telomerase activator. But what it can do is to
help your mitochondria body burn off fats, reshape LDL cholesterol to be
more light and fluffy and thereby less likely to trigger cardiovascular
disease, and in the process reduce inflammation, glycation, and oxidative
damage that may themselves lead to more rapid shortening of telomeres.
Carnitine has no significant risk when used in reasonable quantities
(generally regarded as up to around 2000mg per day) because it is a
natural healthy nutritional component of commonly consumed red meats such
as beef that is not present in sufficient quantities in most other food
sources. Most people who are trying to “eat healthy” often suffer from
low carnitine levels by following the common advice to avoid
conventionally prepared fatty red meats. Doing so does help avoid
unhealthy omega 6 fats and glycated proteins, but it wipes out the most
plentiful source of carnitine in the diet. Thus carnitine supplements are
a great way to get back this important mitochondrial nutrient in
combination with a diet low in fatty red meats. Take a look at
<a href="http://emediahealth.com/2011/04/12/l-carnitine-helps-reduce-ldl-cholesterol-triglycerides-blood-glucose-and-insulin-in-fatty-liver-disease-and-diabetes-patients/" target="_blank">
L-Carnitine Helps Reduce LDL Cholesterol, Triglycerides, Blood Glucose,
and Insulin in Fatty Liver Disease and Diabetes Patients</a> and
<a href="http://emediahealth.com/2011/04/20/vegetarians-may-suffer-shorter-life-due-to-carnitine-carnosine-and-vitamin-b12-deficiencies/" target="_blank">
Vegetarians May Suffer Shorter Life Due to Carnitine, Carnosine, and
Vitamin B12 Deficiencies</a> for more information.<br><br>
To learn more about how lengthening telomeres is just one component of a
complete anti-aging protocol, see
<a href="http://emediahealth.com/2010/10/15/ta-65-telomere-lengthening-just-one-part-of-anti-aging-healthcare/" target="_blank">
TA-65 Telomere Lengthening Just One Part of Anti-Aging
Healthcare</a>.<br><br>
</font><h3><b>Accusations of Financial Conflicts of
Interest</b></h3><font size="3">Some biomedical researchers are criticizing
the researchers behind the recent TA-65 study for financial conflict of
interest as they have been involved in the development of TA-65 or
operations of businesses offering related anti-aging testing services
such as telomere length measurement. In general, it has been clear for
decades that the people interested in the field of anti-aging medicine
often have both a strong personal interest in the topic and also make
their livings from their work in the field. They certainly could be
influenced by monetary considerations. But that is true of anybody
working in biomedical research, even many who think they have no
conflicts of interest.<br><br>
For example, Judith Campisi of California’s Buck Institute for Research
on Aging points to how Maria Blasco is involved in a start-up for-profit
business offering telomere length measurement testing services. She finds
the timing of the research study’s release to be suspicious given the
recent launch of Blasco’s new company Life Lengths.<br><br>
What is naive or even disingenuous on the part of critics such as Campisi
is their failure to admit they may have financial motivations themselves.
The success of competing anti-aging supplements such as TA-65 or drugs in
development such as TAT2 represents a financial threat to themselves. If
TA-65 or any supplement or drug were to be conclusively shown to have
life-lengthening properties and thereby become widely used, it could
endanger the ability of these critics to continue their research in their
areas of specialization. That’s the case even if these critics are not
working in what is considered strictly anti-aging medicine. For instance,
if TA-65 or Geron’s TAT2 or other astragalus derivatives were someday
shown to be highly effective and became inexpensive enough for widespread
use for immune system boosting in people with chronic viral infections
such as herpes and AIDS, it could represent a significant financial risk
to thousands of employees of companies and institutes selling widely used
anti-viral medications.<br><br>
Ultimately, it is very easy to toss around the charge of financial bias
regarding anybody working in biomedical research but virtually impossible
to conclusively prove there is no such conflict of interest. Scientists
often work as competitors to each other, even if they have no financial
ownership in their employers or any businesses in the biomedical field.
Just look at the history of the discovery of DNA and its structure to
understand that publicly recognized giants in the field such as Watson,
Crick, Pauling, Wilkins, Franklin, and others were both fiercely
competitive with each other and quick to use discoveries the others made
even for their own purposes even though there was no immediately obvious
way to make a huge profit out of such discoveries at the time.<br><br>
Don’t let claims of financial bias scare you too much. Consumers are
going to have to practice a certain level of “buyer beware” thinking,
carefully considering that virtually everybody writing about anti-aging
nutrition and medicine has some level of financial interest in it just as
is the case in basically every other marketplace. That’s why it is
important to look for multiple studies behind any type of health care
product. Any one or two studies could be really flawed or outright
biased, but if you can find 10 or 20 studies from a variety of
universities, clinics, and companies backing up the effectiveness of a
particular drug or nutrient then it is unlikely that all of them will be
flawed, especially if most show similar benefits and discussion of how
the drug or nutrient works and any side effects it may have. Even after
you select a product that looks promising, be sure to give it a try with
some objective attempts to measure its impact on your health such as via
routine blood testing to monitor for effect.<br><br>
</font><h3><b>Further
Reading</b></h3><font size="3">
<a href="http://emediahealth.com/2010/11/27/ta-65-customer-interviewed-by-cbs-los-angeles-channel-2/" target="_blank">
TA-65 Customer Interviewed by CBS Los Angeles Channel 2</a><br><br>
<a href="http://emediahealth.com/2010/10/19/how-astragalus-extracts-help-immune-system-fight-viruses" target="_blank">
How Astragalus Extracts Help Immune System Fight Viruses</a><br><br>
<a href="http://emediahealth.com/2010/10/15/ta-65-telomere-lengthening-just-one-part-of-anti-aging-healthcare/" target="_blank">
TA-65 Telomere Lengthening Just One Part of Anti-Aging
Healthcare</a><br><br>
<a href="http://emediahealth.com/2009/05/15/is-ta-65-the-means-to-immortality" target="_blank">
Is TA-65 the Means to Immortality?</a><br><br>
<a href="http://angiemedia.com/?p=4283" target="_blank">TA-65 Telomere Activation and
Right to Healthcare Choice</a><br><br>
<a href="http://www.tkqlhce.com/mb116mu2-u1HLQPNKLOHJIMRNKNK?url=http%3A%2F%2Fwww.lef.org%2Fnews%2FLefDailyNews.htm%3FNewsID%3D11045" target="_blank">
Breakthrough in vivo Scientific Study Published: TA-65 Increases
Healthspan, Renews Organ Systems, and Increases Critically Short Telomere
Lengths</a><br><br>
<a href="http://www.kqzyfj.com/a1107cy63y5LPUTROPSLNMQVRORO?url=http%3A%2F%2Fwww.lef.org%2Fmagazine%2Fmag2009%2Faug2009_Turning-on-Immortality-The-Debate-Over-Telomerase-Activation_01.htm" target="_blank">
Turning on Immortality: The Debate Over Telomerase
Activation</a><br><br>
<a href="http://www.ncbi.nlm.nih.gov/pubmed/21426483" target="_blank">The telomerase
activator TA-65 elongates short telomeres and increases health span of
adult/old mice without increasing cancer incidence (PubMed)</a><br><br>
<a href="http://www.thedailybeast.com/blogs-and-stories/2011-04-11/anti-aging-pill-new-study-on-ta-65-sparks-controversy/#" target="_blank">
New Anti-Aging Pill Under Fire</a><br><br>
<a href="http://www.nature.com/scitable/topicpage/discovery-of-dna-structure-and-function-watson-397" target="_blank">
Discovery of DNA Structure and Function: Watson and Crick</a><br>
<hr>
These statements have not been evaluated by the Food and Drug
Administration. The products mentioned in this post and on this website
are not intended to diagnose, treat, cure or prevent any disease.<br>
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</li></ul>This entry was posted in
<a href="http://emediahealth.com/category/anti-aging/" target="_blank">Anti-Aging</a>,
<a href="http://emediahealth.com/category/cancer/" target="_blank">Cancer</a>,
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, <a href="http://emediahealth.com/category/diabetes/" target="_blank">Diabetes</a>,
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<a href="http://emediahealth.com/category/mitochondrial-health/" target="_blank">
Mitochondrial Health</a>,
<a href="http://emediahealth.com/category/vitamins-supplements/" target="_blank">Vitamins
& Supplements</a> and tagged
<a href="http://emediahealth.com/tag/agueda-tejera/" target="_blank">Agueda Tejera</a>,
<a href="http://emediahealth.com/tag/bruno-bernardes-de-jesus/" target="_blank">Bruno
Bernardes de Jesus</a>,
<a href="http://emediahealth.com/tag/calvin-harley/" target="_blank">Calvin Harley</a>,
<a href="http://emediahealth.com/tag/elsa-vera/" target="_blank">Elsa Vera</a>,
<a href="http://emediahealth.com/tag/geron-corporation/" target="_blank">Geron
Corporation</a>,
<a href="http://emediahealth.com/tag/judith-campisi/" target="_blank">Judith Campisi</a>,
<a href="http://emediahealth.com/tag/kerstin-schneeberger/" target="_blank">Kerstin
Schneeberger</a>,
<a href="http://emediahealth.com/tag/maria-blasco/" target="_blank">Maria Blasco</a>,
<a href="http://emediahealth.com/tag/ta-65/" target="_blank">TA-65</a>,
<a href="http://emediahealth.com/tag/tat2/" target="_blank">TAT2</a>,
<a href="http://emediahealth.com/tag/telomerase/" target="_blank">telomerase</a>,
<a href="http://emediahealth.com/tag/telomerase-activator/" target="_blank">telomerase
activator</a>,
<a href="http://emediahealth.com/tag/telomeres/" target="_blank">telomeres</a>. Bookmark
the
<a href="http://emediahealth.com/2011/04/23/ta-65-anti-aging-study-shows-health-increase-in-adult-and-old-mice-from-telomerase-lengthening/" target="_blank">
permalink</a>.<br><br>
=================================================================<br>
<a href="http://onlinelibrary.wiley.com/doi/10.1111/j.1474-9726.2011.00700.x/abstract" target="_blank">
http://onlinelibrary.wiley.com/doi/10.1111/j.1474-9726.2011.00700.x/abstract</a>
<br>
============================<br>
</font><h1><b>The telomerase activator TA-65 elongates short telomeres
and increases health span of adult/old mice without increasing cancer
incidence</b></h1>
<ol>
<li><font size="3">Bruno Bernardes de Jesus<sup>1</sup>,
</font></li><font size="3"><li>Kerstin Schneeberger<sup>1</sup>,
</li><li>Elsa Vera<sup>1,2</sup>,
</li><li>Agueda Tejera<sup>1</sup>,
</li><li>Calvin B. Harley<sup>3</sup>,
</li><li>Maria A. Blasco<sup>1</sup>
</li></font></ol><br>
Article first published online: 14 APR 2011<br><br>
DOI: 10.1111/j.1474-9726.2011.00700.x<br><br>
© 2011 The Authors. Aging Cell © 2011 Blackwell Publishing Ltd/Anatomical
Society of Great Britain and Ireland<br><br>
Issue <br>
<img src="" alt="Cover image for Vol. 10 Issue 2" width="101" height="131">
<br><br>
<h2><b>Aging Cell</b></h2><font size="3">Early View (Online Version
of Record published before inclusion in an issue)<br><br>
Additional
Information<a href="http://onlinelibrary.wiley.com/doi/10.1111/j.1474-9726.2011.00700.x/abstract#" target="_blank">
(Show All)</a><br><br>
<a href="http://onlinelibrary.wiley.com/doi/10.1111/j.1474-9726.2011.00700.x/abstract#" target="_blank">
How to
Cite</a>
<a href="http://onlinelibrary.wiley.com/doi/10.1111/j.1474-9726.2011.00700.x/abstract#" target="_blank">
Author
Information</a>
<a href="http://onlinelibrary.wiley.com/doi/10.1111/j.1474-9726.2011.00700.x/abstract#" target="_blank">
Publication History</a><br><br>
</font><h4><b>How to Cite</b></h4><font size="3">de Jesus, B. B.,
Schneeberger, K., Vera, E., Tejera, A., Harley, C. B. and Blasco, M. A.
(2011), The telomerase activator TA-65 elongates short telomeres and
increases health span of adult/old mice without increasing cancer
incidence. Aging Cell, 10: no. doi:
10.1111/j.1474-9726.2011.00700.x<br><br>
</font><h4><b>Author Information</b></h4>
<ol>
<li><font size="3"><sup>1</sup><br><br>
</font></li><font size="3"><li>Telomeres and Telomerase Group, Molecular Oncology Program, Spanish
National Cancer Centre, Melchor Fernández Almagro 3, Madrid E-28029,
Spain
</li><li><sup>2</sup><br>
</li><li>Life Length, Agustín de Betancourt 21, Madrid E-28003, Spain
</li><li><sup>3</sup><br>
</li><li>Telome Health, Menlo Park, CA 94025, USA
</li></font></ol><br>
*Correspondence: <i>Maria A. Blasco, Telomeres and Telomerase Group,
Molecular Oncology Program, Spanish National Cancer Centre, Melchor
Fernández Almagro 3, Madrid, E-28029, Spain. Tel.: <a href="tel:%2B34-917328034" value="+34917328034" target="_blank">+34-917328034</a>; fax:
<a href="tel:%2B34-917328028" value="+34917328028" target="_blank">+34-917328028</a>;
e-mail:</i><a href="mailto:mblasco@cnio.es" target="_blank">mblasco@cnio.es</a><br><br>
<h4><b>Publication History</b></h4>
<ol>
<li><font size="3">Article first published online: 14 APR 2011
</font></li><font size="3"><li>Accepted manuscript online: 22 MAR 2011 09:26AM EST
</li><li>Accepted for publication <i>9th February 2011</i>
</li></font></ol><br>
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<ul>
<li>Abstract
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<h3><b>Keywords:</b></h3>
<ul>
<li><font size="3">telomerase activation;
</font></li><font size="3"><li>TA-65;
</li><li>telomere length;
</li><li>aging;
</li><li>mouse
</li></font></ul><br>
<h3><b>Summary</b></h3><font size="3">Here, we show that a
small-molecule activator of telomerase (TA-65) purified from the root of
<i>Astragalus membranaceus</i> is capable of increasing average telomere
length and decreasing the percentage of critically short telomeres and of
DNA damage in haploinsufficient mouse embryonic fibroblasts (MEFs) that
harbor critically short telomeres and a single copy of the telomerase RNA
<i>Terc</i> gene (G3 <i>Terc<sup>+/ </sup></i>MEFs). Importantly, TA-65
does not cause telomere elongation or rescue DNA damage in similarly
treated telomerase-deficient G3 <i>Terc<sup> / </sup></i>littermate MEFs.
These results indicate that TA-65 treatment results in
telomerase-dependent elongation of short telomeres and rescue of
associated DNA damage, thus demonstrating that TA-65 mechanism of action
is through the telomerase pathway. In addition, we demonstrate that TA-65
is capable of increasing mouse telomerase reverse transcriptase levels in
some mouse tissues and elongating critically short telomeres when
supplemented as part of a standard diet in mice. Finally, TA-65 dietary
supplementation in female mice leads to an improvement of certain
health-span indicators including glucose tolerance, osteoporosis and skin
fitness, without significantly increasing global cancer incidence.<br>
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