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</o:shapelayout></xml><![endif]--></head><body lang=EN-US link=blue vlink=purple><div class=WordSection1><p class=MsoNormal><span style='color:#1F497D'><o:p> </o:p></span></p><p class=MsoPlainText><span style='color:#1F497D'><o:p> </o:p></span></p><p class=MsoPlainText><span style='color:#1F497D'>This one test should be simple: find a bexarotene patient with Alzheimer’s. I look at the annual sales figures for Targretin which one source gave as 141 million, divide by 1200 a month and divide that by 12, and I get on the order of ten thousands patients taking Targretin. Skin cancer disproportionately effects older people, so I figure if bexarotene does not have any effect on Alzheimer’s then probably several hundred Targretin patients should have Alzheimers right now. So now all you internet hipsters, here is your assignment: find a Targretin-devouring patient with Alzheimer’s.<o:p></o:p></span></p><p class=MsoPlainText><span style='color:#1F497D'><o:p> </o:p></span></p><p class=MsoPlainText><span style='color:#1F497D'>Or rather offer a suggestion: how do we find these patients?<o:p></o:p></span></p><p class=MsoPlainText><span style='color:#1F497D'><o:p> </o:p></span></p><p class=MsoPlainText><span style='color:#1F497D'>Would not a huge open volunteer database be useful here?<o:p></o:p></span></p><p class=MsoPlainText><span style='color:#1F497D'><o:p> </o:p></span></p><p class=MsoPlainText><span style='color:#1F497D'>Could not we talk to memory care facilities and find out if they have Targretin-eaters among their patients?<o:p></o:p></span></p><p class=MsoPlainText><span style='color:#1F497D'><o:p> </o:p></span></p><p class=MsoPlainText><span style='color:#1F497D'>spike<o:p></o:p></span></p></div></body></html>