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</o:shapelayout></xml><![endif]--></head><body lang=EN-US link=blue vlink=purple><div class=WordSection1><p class=MsoPlainText><o:p> </o:p></p><p class=MsoPlainText>>... On Behalf Of Jeff Davis<br>Subject: Re: [ExI] good bexarotene article</p><p class=MsoPlainText><o:p> </o:p></p><p class=MsoPlainText>On Wed, Feb 15, 2012 at 4:28 PM, spike <<a href="mailto:spike66@att.net"><span style='color:windowtext;text-decoration:none'>spike66@att.net</span></a>> wrote:<o:p></o:p></p><p class=MsoPlainText>>> Ow, discouraging realization, it's been six days since the Scientific <o:p></o:p></p><p class=MsoPlainText>> American article came out. Surely someone somewhere has done this <o:p></o:p></p><p class=MsoPlainText>> test by now. If it worked in humans the way it does in mice, we would <o:p></o:p></p><p class=MsoPlainText>> likely have heard it by about Sunday afternoon... spike<o:p></o:p></p><p class=MsoPlainText><o:p> </o:p></p><p class=MsoPlainText>>...Perhaps someone should give the news people a call, see what's keeping them?<o:p></o:p></p><p class=MsoPlainText><o:p> </o:p></p><p class=MsoPlainText>Jeff<o:p></o:p></p><p class=MsoPlainText><o:p> </o:p></p><p class=MsoPlainText>_______________________________________________<o:p></o:p></p><p class=MsoPlainText><o:p> </o:p></p><p class=MsoPlainText><span style='color:black'><o:p> </o:p></span></p><p class=MsoPlainText><span style='color:black'>Saturday's Wall Street Journal commented thus:<o:p></o:p></span></p><p class=MsoPlainText><span style='color:black'><o:p> </o:p></span></p><p class=MsoNormal><span style='color:black'>Targretin is generally used at the highest tolerated dose in cancer patients, according to Keith Flaherty, a skin-cancer specialist at Harvard Medical School. The dosage that might be needed to treat Alzheimer's is unclear but is likely far lower, he said.<o:p></o:p></span></p><p class=MsoPlainText><span style='color:black'><o:p> </o:p></span></p><p class=MsoPlainText><span style='color:black'><a href="http://online.wsj.com/article/SB10001424052970204642604577215382600942356.html">http://online.wsj.com/article/SB10001424052970204642604577215382600942356.html</a><o:p></o:p></span></p><p class=MsoPlainText><span style='color:black'><o:p> </o:p></span></p><p class=MsoPlainText><span style='color:black'>This is good news indeed. Targretin is known to be a mild drug for side effects, and having Dr. Flaherty comment that the AD dosage is likely to be far lower is a good thing.<o:p></o:p></span></p><p class=MsoPlainText><span style='color:black'><o:p> </o:p></span></p><p class=MsoPlainText><span style='color:black'>I am still looking for the online comments by people who have tried this. Apparently Targretin is not easy to find.<o:p></o:p></span></p><p class=MsoPlainText><span style='color:black'><o:p> </o:p></span></p><p class=MsoPlainText><span style='color:black'>spike<o:p></o:p></span></p><p class=MsoPlainText><span style='color:black'><o:p> </o:p></span></p></div></body></html>