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</o:shapelayout></xml><![endif]--></head><body lang=EN-US link=blue vlink=purple><div class=WordSection1><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal><b><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'>>…</span></b><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'> <b>On Behalf Of </b>James Clement<br><b>Subject:</b> Re: [ExI] Jaw-dropping CWRU Alzheimer's breakthrough?<o:p></o:p></span></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal>Spike says:<o:p></o:p></p><div><blockquote style='border:none;border-left:solid #CCCCCC 1.0pt;padding:0in 0in 0in 6.0pt;margin-left:4.8pt;margin-right:0in'><div><div><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>"This notion can be extended to the kinds of advances we transhumanists might expect</span><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>…</span><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Wouldn’t be fair you know." </span><o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><o:p> </o:p></p></div></div></blockquote><div><p class=MsoNormal style='margin-bottom:12.0pt'><span style='color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal style='margin-bottom:12.0pt'><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal style='margin-bottom:12.0pt'><span style='color:#1F497D'>James wrote:<o:p></o:p></span></p><p class=MsoNormal style='margin-bottom:12.0pt'><br><span style='color:#1F497D'>>…</span>It's the 10 years and $800+ Million that it costs to satisfy the FDA that makes these drugs cost $50000to $100,000 per year. I can bet that the active ingredients cost no more than a few hundredths of a cent per dose. But to amortize the cost of approval over the number of expected sales and then make a profit - that boosts it to this extreme level<span style='color:#1F497D'>…<o:p></o:p></span></p><p class=MsoNormal style='margin-bottom:12.0pt'><span style='color:#1F497D'>OK thanks James, ja, I agree, and there is nada I can do about that. Sorry Eisai, the cat is out of the bag and there is no getting her back in. There are plenty of us out here willing to risk a tenth of a milligram of whatever impurities are in 10 mg of reagent grade bexarotene, going around your ultra-pure Targretin, sorry. If I could legally get Targretin, I would use that, cut it into ten doses (I know how to do that and I have the equipment) mix that with alcohol to insure it is completely dissolved to the molecular level, and down the hatch. I am willing to experiment on myself, before I suggest it to anyone else. This is a once in a lifetime opportunity.<o:p></o:p></span></p><p class=MsoNormal style='margin-bottom:12.0pt'><br><br><span style='color:#1F497D'>>…</span>Short of getting rid of the FDA, one remedy is outright piracy<span style='color:#1F497D'>…<o:p></o:p></span></p><p class=MsoNormal style='margin-bottom:12.0pt'><span style='color:#1F497D'>Disagree sir, with all due respect, and you know I love you like a brother, but THIS IS NOT PIRACY to use bexarotene off-label, no sir. Eisai does not own that molecule and every use and misuse to which it might be put, no way. I do respect the notion of intellectual property, but I do not feel it is stealing anything from Eisai to use reagent grade bex, or Targretin for that matter.<o:p></o:p></span></p><p class=MsoNormal style='margin-bottom:12.0pt'><span style='color:#1F497D'>Thanks for the input James. Others please? If you have already hit five posts today, don’t worry about it, I won’t notice, and no one is complaining. I need guidance riiiiight noooowwwww. <o:p></o:p></span></p><p class=MsoNormal style='margin-bottom:12.0pt'><span style='color:#1F497D'>Dr. Rafal, are ye out there, me lad?<o:p></o:p></span></p><p class=MsoNormal style='margin-bottom:12.0pt'><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>spike<o:p></o:p></span></p></div></div></div></body></html>