<html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns="http://www.w3.org/TR/REC-html40"><head><meta http-equiv=Content-Type content="text/html; charset=us-ascii"><meta name=Generator content="Microsoft Word 14 (filtered medium)"><style><!--
/* Font Definitions */
@font-face
{font-family:Calibri;
panose-1:2 15 5 2 2 2 4 3 2 4;}
@font-face
{font-family:Tahoma;
panose-1:2 11 6 4 3 5 4 4 2 4;}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{margin:0in;
margin-bottom:.0001pt;
font-size:12.0pt;
font-family:"Times New Roman","serif";}
a:link, span.MsoHyperlink
{mso-style-priority:99;
color:blue;
text-decoration:underline;}
a:visited, span.MsoHyperlinkFollowed
{mso-style-priority:99;
color:purple;
text-decoration:underline;}
p
{mso-style-priority:99;
mso-margin-top-alt:auto;
margin-right:0in;
mso-margin-bottom-alt:auto;
margin-left:0in;
font-size:12.0pt;
font-family:"Times New Roman","serif";}
span.EmailStyle18
{mso-style-type:personal;
font-family:"Calibri","sans-serif";
color:#1F497D;}
span.EmailStyle19
{mso-style-type:personal-reply;
font-family:"Calibri","sans-serif";
color:#1F497D;}
.MsoChpDefault
{mso-style-type:export-only;
font-size:10.0pt;}
@page WordSection1
{size:8.5in 11.0in;
margin:1.0in 1.0in 1.0in 1.0in;}
div.WordSection1
{page:WordSection1;}
--></style><!--[if gte mso 9]><xml>
<o:shapedefaults v:ext="edit" spidmax="1026" />
</xml><![endif]--><!--[if gte mso 9]><xml>
<o:shapelayout v:ext="edit">
<o:idmap v:ext="edit" data="1" />
</o:shapelayout></xml><![endif]--></head><body lang=EN-US link=blue vlink=purple><div class=WordSection1><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><div><div style='border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0in 0in 0in'><p class=MsoNormal><b><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'>From:</span></b><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'> spike [mailto:spike66@att.net] <br><br><b><span style='color:#1F497D'><o:p></o:p></span></b></span></p></div></div><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>>…</span><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Sooner or later, it will occur to the population that if bexarotene helps Alzheimer’s patients, perhaps it will also help those who do not have Alzheimer’s but whose youth occurred tragically many years ago, and these have sufficient funds to finance the meds themselves. Why not</span><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>? s</span><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>pike</span><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Well hell, since I offered us all permission to answer our own questions, I will do so now. <o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Why not try bexarotene myself? If I can get some of this stuff, I am willing to rely on my own calculations and research regarding bexarotene manufacturing, its intermediate components and its catalysts, aluminum trichloride and sodium hydroxide, the concentrations thereof, and my studies regarding solubility. Why not? <o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>The stoner crowd is willing take appalling risks to poke junk into their veins and sniff or eat god knows what, manufactured by who knows, with huge motive for all intermediate handlers to add who knows to increase profits, and yet no problem, up the nose with it, fearless as hungry lion. But when we get a known medication taken not for kicks but to possibly defeat a horrifying disease, suddenly we go all wobbly kneed? Come on, someone explain this to me please.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>No one? OK, good, here’s the plan, if I can get some of this (still looking.) A therapeutic dose of bexarotene is 75 mg. My suspicion is that it is not completely dissolved to the molecular level in the form of Targretin, but I might be wrong, so my strategy is to take a tenth of that dose, in a form I know is completely dissolved, in about 10 grams of alcohol. Then I watch and test myself for any signs of hypothyroidism or any increase in memory, or anything else, and I am FREEEEE of all ethical dilemmas, ja? I cannot be faulted for taking the stuff myself, right? Cannot I pretend that it is some kind of dope, in which case our modern society’s notions of ethics mysteriously excuse the devourer from all responsibility and accountability? Why do the stoners get a free pass but we amateur researchers don’t?<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>Come on, my fellow extropians, toss me a bone here, offer a suggestion, talk me out of this if there is a good reason this is a bad idea. Otherwise, suggest a place where I might get some bexarotene. I feel like I am sailing uncharted waters alone.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'>spike <o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p></div></body></html>