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</o:shapelayout></xml><![endif]--></head><body lang=EN-US link=blue vlink=purple><div class=WordSection1><p class=MsoNormal><span style='color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal><span style='color:#1F497D'><o:p> </o:p></span></p><div><div style='border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0in 0in 0in'><p class=MsoNormal><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'><br><b>Subject:</b> RE: [ExI] Jaw-dropping CWRU Alzheimer's breakthrough?<o:p></o:p></span></p></div></div><p class=MsoNormal><o:p> </o:p></p><p class=MsoPlainText><o:p> </o:p></p><p class=MsoPlainText><o:p> </o:p></p><p class=MsoPlainText>Hey cool, a report came out from the Salk Institute in December about a new Alzheimer’s drug they were testing, which they just called compound J147, perhaps to prevent a stampede of amateur pharmacists from experimenting with it on themselves and their family members. <o:p></o:p></p><p class=MsoPlainText><o:p> </o:p></p><p class=MsoPlainText><a href="http://www.youtube.com/watch?feature=player_embedded&v=xz_0zujJjD0">http://www.youtube.com/watch?feature=player_embedded&v=xz_0zujJjD0</a><o:p></o:p></p><p class=MsoPlainText><o:p> </o:p></p><p class=MsoPlainText>They did show a screen shot of the molecule, which I captured at one minute forty seconds. <span style='color:black'>Here’s the cool part. Notice the similarity to bexarotene on the right below:</span><o:p></o:p></p><p class=MsoPlainText><o:p> </o:p></p><p class=MsoPlainText><o:p> </o:p></p><p class=MsoPlainText><!--[if gte vml 1]><v:shapetype id="_x0000_t75" coordsize="21600,21600" o:spt="75" o:preferrelative="t" path="m@4@5l@4@11@9@11@9@5xe" filled="f" stroked="f">
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</v:shape><![endif]--><![if !vml]><span style='mso-ignore:vglayout;position:absolute;z-index:251659264;margin-left:580px;margin-top:21px;width:231px;height:279px'><img width=231 height=279 src="cid:image002.png@01CCF803.977920F0" v:shapes="_x0000_s1026"></span><![endif]><span style='color:black'><img border=0 width=447 height=336 id="Picture_x0020_2" src="cid:image007.jpg@01CCF78D.068DFDC0"><o:p></o:p></span></p><p class=MsoPlainText><span style='color:black'><o:p> </o:p></span></p><p class=MsoPlainText><span style='color:black'><o:p> </o:p></span></p><p class=MsoPlainText><span style='color:black'>From the screen shot, J147 has nitrogens in two places where bexarotene has carbons, the methyl groups are slightly different, the double bond to oxygen is moved over to a different position and there are three chlorines substituted on one of the methyl groups. I would call J147 (left) a chemical cousin to bexarotene. Source: US patent from 1998. <o:p></o:p></span></p><p class=MsoPlainText><span style='color:black'><o:p> </o:p></span></p><p class=MsoPlainText><span style='color:black'>It wouldn’t surprise me if a family of chemicals similar to bexarotene may all have some impact on beta amyloids. We know that the statins are a group of similar chemicals. So if we have stumbled upon a kind of Lipitor for the brain, there will be plenty of one-offs from which to choose. What I want to know is if Salk Institute and Case Western influenced each other, or if the two groups discovered this independently.<o:p></o:p></span></p><p class=MsoPlainText><span style='color:black'><o:p> </o:p></span></p><p class=MsoPlainText><span style='color:black'>We know ways to take a known molecule and synthesize a chemical one-off through substitution. Chlorine for hydrogen on your outermost methyl is an easy one. If we need to go around patent 5,780,676 which still has a little over three years in it, that might be the way to do it. Again the stoner crowd may come riding to the rescue: they do stuff like this all the time. They can take some controlled stone-forming chemical which is illegal, do a one-off and create a perfectly legal stone-former. So they should be able to teach us a few of those tricks, in which case they would aid humanity bigtime.<o:p></o:p></span></p><p class=MsoPlainText><span style='color:black'><o:p> </o:p></span></p><p class=MsoPlainText><span style='color:black'>This is going to be an interesting next few months as clinical test results start coming in.<o:p></o:p></span></p><p class=MsoPlainText><span style='color:black'><o:p> </o:p></span></p><p class=MsoPlainText><span style='color:black'>spike<o:p></o:p></span></p><p class=MsoPlainText><span style='color:black'><o:p> </o:p></span></p><p class=MsoPlainText><span style='color:black'><o:p> </o:p></span></p><p class=MsoPlainText><span style='color:black'><o:p> </o:p></span></p><p class=MsoPlainText><span style='color:black'><o:p> </o:p></span></p><p class=MsoPlainText><span style='color:black'><o:p> </o:p></span></p><p class=MsoPlainText><span style='color:black'><o:p> </o:p></span></p><p class=MsoPlainText><span style='color:black'><o:p> </o:p></span></p></div></body></html>