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</o:shapelayout></xml><![endif]--></head><body lang=EN-US link=blue vlink=purple><div class=WordSection1><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif'><o:p> </o:p></span></p><p class=MsoNormal><b><span style='font-size:11.0pt;font-family:"Calibri",sans-serif'>From:</span></b><span style='font-size:11.0pt;font-family:"Calibri",sans-serif'> extropy-chat [mailto:extropy-chat-bounces@lists.extropy.org] <b>On Behalf Of </b>John Clark<br><b>…</b></span><span style='font-family:"Arial",sans-serif'><o:p></o:p></span></p><div><div><div><p class=MsoNormal><o:p> </o:p></p></div><div><div><p class=MsoNormal><span style='font-family:"Arial",sans-serif'>>…</span><span style='font-size:13.5pt;font-family:"Arial",sans-serif'>To me one of the most interesting things about CRISPR is that we can use it to enable Gene Drive. … You could use this technique to make mosquitoes extinct. </span><span style='font-family:"Arial",sans-serif'><o:p></o:p></span></p></div><div><p class=MsoNormal><span style='font-family:"Arial",sans-serif'><o:p> </o:p></span></p></div><div><p class=MsoNormal><span style='font-family:"Arial",sans-serif'><a href="https://www.technologyreview.com/s/600689/we-have-the-technology-to-destroy-all-zika-mosquitoes/">https://www.technologyreview.com/s/600689/we-have-the-technology-to-destroy-all-zika-mosquitoes/</a> <o:p></o:p></span></p></div><div><p class=MsoNormal><span style='font-family:"Arial",sans-serif'><o:p> </o:p></span></p></div><div><p class=MsoNormal><span style='font-size:13.5pt;font-family:"Arial",sans-serif'> John K Clark <o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:16.0pt;font-family:"Calibri",sans-serif'> Ja, or another slight variation on the theme: breed mosquitoes with some kind of DNA variation-driver until we discover a mosquito which does not bite humans. Then read that genome, synthesize it, insert it into a population of existing indigenous and particularly virile strain of mosquitoes. <o:p></o:p></span></p><p class=MsoNormal><span style='font-size:16.0pt;font-family:"Calibri",sans-serif'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:16.0pt;font-family:"Calibri",sans-serif'>The no-people gene linked to the lotsa-larvae gene competes with the indigenous species and spreads both. We could end up with more mosquitoes than before, but the humans would scarcely notice they were there.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:16.0pt;font-family:"Calibri",sans-serif'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:16.0pt;font-family:"Calibri",sans-serif'>There is serious debate about the environmental impact of complete eradication of mosquitoes. Perhaps they perform some unknown beneficial function (it better be a really good one to convince me to keep the needlenose bastards.) This approach keeps everyone happy.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:16.0pt;font-family:"Calibri",sans-serif'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:16.0pt;font-family:"Calibri",sans-serif'>That would be a hell of a breakthrough: breed mosquitoes that don’t bite humans but bite rats.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:16.0pt;font-family:"Calibri",sans-serif'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:16.0pt;font-family:"Calibri",sans-serif'>spike<o:p></o:p></span></p></div><div><p class=MsoNormal><span style='font-family:"Arial",sans-serif'><o:p> </o:p></span></p></div><div><p class=MsoNormal><span style='font-family:"Arial",sans-serif'><o:p> </o:p></span></p></div><div><p class=MsoNormal><span style='font-family:"Arial",sans-serif'><o:p> </o:p></span></p></div></div><div><p class=MsoNormal><o:p> </o:p></p></div><div><p class=MsoNormal><o:p> </o:p></p></div><div><p class=MsoNormal><o:p> </o:p></p><blockquote style='border:none;border-left:solid #CCCCCC 1.0pt;padding:0in 0in 0in 6.0pt;margin-left:4.8pt;margin-right:0in'><div><div><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><o:p> </o:p></p></div></div><p class=MsoNormal><o:p> </o:p></p></blockquote></div><p class=MsoNormal><o:p> </o:p></p></div></div></div></body></html>