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</o:shapelayout></xml><![endif]--></head><body bgcolor=white lang=EN-US link="#0563C1" vlink="#954F72"><div class=WordSection1><p class=MsoNormal><span style='color:windowtext'><o:p> </o:p></span></p><p class=MsoNormal><span style='color:windowtext'><o:p> </o:p></span></p><div><div style='border:none;border-top:solid #E1E1E1 1.0pt;padding:3.0pt 0in 0in 0in'><p class=MsoNormal><b><span style='color:windowtext'>From:</span></b><span style='color:windowtext'> extropy-chat [mailto:extropy-chat-bounces@lists.extropy.org] <b>On Behalf Of </b>Anders Sandberg<br><b>Sent:</b> Thursday, April 07, 2016 3:36 AM<br><b>To:</b> ExI chat list <extropy-chat@lists.extropy.org><br><b>Subject:</b> Re: [ExI] crispr question<o:p></o:p></span></p></div></div><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal>On 2016-04-07 06:01, spike wrote:<br><br><span style='font-size:12.0pt'><o:p></o:p></span></p><blockquote style='margin-top:5.0pt;margin-bottom:5.0pt'><p class=MsoNormal><span style='color:windowtext'>…</span><o:p></o:p></p><p class=MsoNormal> <o:p></o:p></p><p class=MsoNormal>As you understand it and extrapolate to a reasonable estimate of your lifespan, have we any reason to think that if we had an organism’s complete genome, we could synthesize that file into a DNA strand using CRISPR or any other reasonably foreseeable technology?<o:p></o:p></p></blockquote><p class=MsoNormal><span style='font-size:12.0pt;font-family:"Times New Roman",serif'><br></span><span style='font-size:12.0pt;font-family:"Times New Roman",serif;color:windowtext'>>…</span><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>CRISPR doesn't involve synthesizing strands, just putting in or removing sequences at particular spots. <br><br></span><span style='font-size:12.0pt;font-family:"Times New Roman",serif;color:windowtext'>>…</span><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>Current synthesis mainly make short strands that have to be ligated together into genomes; this is cumbersome and limits it to short genomes. However, I have heard that there are technologies emerging that look like they could build entire human-sized genomes.</span>-- <span style='color:windowtext'>…</span>Anders Sandberg<span style='color:windowtext'><o:p></o:p></span></p><pre><span style='color:windowtext'><o:p> </o:p></span></pre><pre><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;color:windowtext'><o:p> </o:p></span></pre><pre><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;color:windowtext'>Cool, so this leads into my next comment. We saw that it was 60 years between the first marginal chess program to the orders-of-magnitude more impressive champion AlphaGo. We know that cheap technology exists in which a prole can get her DNA file. If a number of siblings have that DNA file, they can figure out the genome of their parents, and if several cousins compare their genomes, they can piece together the genomes of their mutual grandparents, second cousins their great grandparents and so on.<o:p></o:p></span></pre><pre><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;color:windowtext'><o:p> </o:p></span></pre><pre><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;color:windowtext'>If we could synthesize a DNA strand by some means using a DNA file, we could perhaps use it to clone someone who lived a long time ago, given sufficient numbers of their descendants have their DNA files.<o:p></o:p></span></pre><pre><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;color:windowtext'><o:p> </o:p></span></pre><pre><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;color:windowtext'>Ja?<o:p></o:p></span></pre><pre><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;color:windowtext'><o:p> </o:p></span></pre><pre><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;color:windowtext'>spike<o:p></o:p></span></pre></div></body></html>