<div dir="ltr"><div class="gmail_default" style="font-family:"comic sans ms",sans-serif;font-size:small;color:rgb(0,0,0)"><span style="font-size:12.8px;font-family:arial,sans-serif;color:rgb(34,34,34)">In my case, you have decades of my postings and I can date when I</span></div><span style="font-size:12.8px">started taking nicotinamide ribosid by my first order. I wonder if</span><br style="font-size:12.8px"><span style="font-size:12.8px">anyone out there has a way to measure cognitive performance from net</span><br style="font-size:12.8px"><div class="gmail_default" style="font-family:"comic sans ms",sans-serif;font-size:small;color:rgb(0,0,0)"><span style="font-size:12.8px;font-family:arial,sans-serif;color:rgb(34,34,34)">postings?</span></div><div class="gmail_default" style="font-family:"comic sans ms",sans-serif;font-size:small;color:rgb(0,0,0)"><br></div><div class="gmail_default" style="font-family:"comic sans ms",sans-serif;font-size:small;color:rgb(0,0,0)">My variability from day to day isn't much, but within days it's huge. I am extremely slow to awaken and am not truly awake for a couple of hours. I try to get started by doing crosswords with coffee. Later in the day I pick up the same puzzle and fill it in rapidly in those places where I got stuck earlier.</div><div class="gmail_default" style="font-family:"comic sans ms",sans-serif;font-size:small;color:rgb(0,0,0)"><br></div><div class="gmail_default" style="font-family:"comic sans ms",sans-serif;font-size:small;color:rgb(0,0,0)">Since you have decades of postings, I assume that the other people who have known you that long could easily tell if you started to get senile. Of course you know about using brain teasers and puzzles as data on decline.</div><div class="gmail_default" style="font-family:"comic sans ms",sans-serif;font-size:small;color:rgb(0,0,0)"><br></div><div class="gmail_default" style="font-family:"comic sans ms",sans-serif;font-size:small;color:rgb(0,0,0)">Skinner, famous for his pigeons, used the 'subject as his own control' method, which is just what you described with your angina example: present A and measure; withdraw A and measure; present A again and measure, and so on. Skinner would do this several times before he was convinced A made a difference. The only problem with this is that we typically take several supplements, and it's just impossible to tell if any interact with others. We assume that drugs act alone and that may be an invalid assumption. I do know that my Synthroid is supposed to be taken with no other drugs, and of course you know about grapefruit juice and its ability to exacerbate the effects of certain drugs.</div><div class="gmail_default" style="font-family:"comic sans ms",sans-serif;font-size:small;color:rgb(0,0,0)"><br></div><div class="gmail_default" style="font-family:"comic sans ms",sans-serif;font-size:small;color:rgb(0,0,0)">bill w</div></div><div class="gmail_extra"><br><div class="gmail_quote">On Sat, Jul 9, 2016 at 1:41 PM, Keith Henson <span dir="ltr"><<a href="mailto:hkeithhenson@gmail.com" target="_blank">hkeithhenson@gmail.com</a>></span> wrote:<br><blockquote class="gmail_quote" style="margin:0 0 0 .8ex;border-left:1px #ccc solid;padding-left:1ex">Mike, as I understand it, the effects of nicotinamide riboside are<br>
more variable on younger people. Why isn't obvious, but it could be<br>
that the level of NAD+ is one of the things when get out of whack as<br>
we get older.<br>
<br>
I am almost 74. At that age, there are a lot of annoying things that<br>
start to happen to you. For me, some of them seem to have backed off,<br>
though if they are due to the nicotinamide riboside, it took several<br>
months for the effects to kick in.<br>
<br>
My life, incidentally, has had previous cases of side effects. I<br>
originally took alagebrium at the same time a big trial was going on.<br>
It didn't help either in the trial or me with the main reason I took<br>
it, but it did have a remarkable effect on the build up of plaque on<br>
my teeth. So I continued to use it, in rather small amounts as a<br>
tooth cleaner.<br>
<br>
The side effect, which I realized after perhaps a year, was to reverse<br>
the progressive angina that had been building up over the previous 10<br>
years. I am fairly sure it was due to the alagebrium because I ran<br>
out and after a few months the angina started to come back. It went<br>
away when I got some more and went back to using it.<br>
<span class="HOEnZb"><font color="#888888"><br>
Keith<br>
</font></span><div class="HOEnZb"><div class="h5"><br>
On Fri, Jul 8, 2016 at 8:14 PM, Mike Dougherty <<a href="mailto:msd001@gmail.com">msd001@gmail.com</a>> wrote:<br>
> On Jul 8, 2016 8:02 PM, "Keith Henson" <<a href="mailto:hkeithhenson@gmail.com">hkeithhenson@gmail.com</a>> wrote:<br>
><br>
>> How many of you are taking nicotinamide riboside? I have been taking<br>
>> it for close to a year. If there are any out there taking it, I would<br>
>> very much like to find out what side effects it had on you and share<br>
>> what I know.<br>
><br>
> I took 30 days worth and didn't notice anything. Admittedly, I want exactly<br>
> sure what I should be paying attention to so to say that it did not have a<br>
> profound impact is not saying it had none.<br>
><br>
><br>
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