<html>
<head>
<meta content="text/html; charset=UTF-8" http-equiv="Content-Type">
</head>
<body bgcolor="#FFFFFF" text="#000000">
<div class="moz-cite-prefix">This makes a great deal of sense if one
abandons the "try to keep tissue naturally revivable" approach and
goes for "preserve information well, darn the viability" approach.
<br>
<br>
What drugs open the BBB? A cursory scan didn't show me anything.
Using ultrasound to do it might be somewhat risky and likely is
too focal. <br>
<br>
On 2016-07-23 17:32, Rafal Smigrodzki wrote:<br>
</div>
<blockquote
cite="mid:CAAc1gFj112iWxrsqtwqki2O-AW3GUKdRSZqAkvemH1_o70qaQA@mail.gmail.com"
type="cite">
<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
<div dir="ltr">I finally got to read my May-June copy of Cryonics,
and I found an interesting update on the case of Kim Suozzi. It
appears that the initial estimates of poor or negligible
cryoprotectant perfusion were incorrect and based on a
reanalysis of CT images with calibrated data the actual
perfusion was quite good, if not perfect.
<div><br>
</div>
<div>The interesting part is that apparently good perfusion was
achieved with minimal brain dehydration, as judged by lack of
shrinkage. The update theorizes that this may have been due to
an opening of the blood-brain barrier, possibly caused by the
combination of neoplasm (brain tumor) and 1 hour of warm
ischemia before perfusion.</div>
<div><br>
</div>
<div>This observation opens a fascinating research opportunity -
if it is true that an opening of the blood-brain barrier
allows vitrification without dehydration-related shrinkage,
then it may be useful to intentionally open the BBB before
perfusion. Lack of shrinkage in a vitrified tissue may make it
easier to perform scanning for uploading, and perhaps might
prevent some loss of information. </div>
<div><br>
</div>
<div>There are drugs that open the BBB, which is not useful for
most cases of cryopreservation but they might allow easy
testing of the idea in animals. If benefits of BBB opening
were to be confirmed in animals, then other techniques could
be developed for use in patients, for example
ultrasound-assisted BBB disruption.</div>
<div><br>
</div>
<div>More research is needed.</div>
<div><br>
</div>
<div>Rafał</div>
</div>
<br>
<fieldset class="mimeAttachmentHeader"></fieldset>
<br>
<pre wrap="">_______________________________________________
extropy-chat mailing list
<a class="moz-txt-link-abbreviated" href="mailto:extropy-chat@lists.extropy.org">extropy-chat@lists.extropy.org</a>
<a class="moz-txt-link-freetext" href="http://lists.extropy.org/mailman/listinfo.cgi/extropy-chat">http://lists.extropy.org/mailman/listinfo.cgi/extropy-chat</a>
</pre>
</blockquote>
<br>
<p><br>
</p>
<pre class="moz-signature" cols="72">--
Dr Anders Sandberg
Future of Humanity Institute
Oxford Martin School
Oxford University
</pre>
</body>
</html>