<div dir="ltr"><div class="gmail_default" style="font-family:comic sans ms,sans-serif;font-size:small;color:#000000">Yes, first, do no harm. Yet experiments in gengineering with mice and other animals is not the same as doing them with people. So how are we going to know that we are doing no harm when we fiddle with human genetics?</div><div class="gmail_default" style="font-family:comic sans ms,sans-serif;font-size:small;color:#000000"><br></div><div class="gmail_default" style="font-family:comic sans ms,sans-serif;font-size:small;color:#000000">We will do it anyway. Just look at antibiotics - when they first came out they cured things previously uncurable things, and germs became a bad word and we bought and are still buying anything that will kill them. Now we know that we created jillions of problems by killing off gut flora with those same life-saving antiobiotics, and increased a host of problems.</div><div class="gmail_default" style="font-family:comic sans ms,sans-serif;font-size:small;color:#000000"><br></div><div class="gmail_default" style="font-family:comic sans ms,sans-serif;font-size:small;color:#000000">My latest book, B</div></div><div class="gmail_extra"><br><div class="gmail_quote">On Wed, Oct 12, 2016 at 10:34 PM, rex <span dir="ltr"><<a href="mailto:rex@nosyntax.net" target="_blank">rex@nosyntax.net</a>></span> wrote:<br><blockquote class="gmail_quote" style="margin:0 0 0 .8ex;border-left:1px #ccc solid;padding-left:1ex">spike <<a href="mailto:spike66@att.net">spike66@att.net</a>> [2016-10-12 14:07]:<br>
<span class="">><br>
><br>
> -----Original Message-----<br>
> From: extropy-chat [mailto:<a href="mailto:extropy-chat-bounces@lists.extropy.org">extropy-chat-bounces@<wbr>lists.extropy.org</a>] On Behalf<br>
>> Of rex<br>
>> There are several terms for it.<br>
>><br>
>> <a href="https://en.wikipedia.org/wiki/Balancing_selection" rel="noreferrer" target="_blank">https://en.wikipedia.org/wiki/<wbr>Balancing_selection</a><br>
>><br>
>> I suspect it's more common than is generally recognized.<br>
<br>
<br>
</span><span class="">> Thanks Rex. You and Stathis identified it as heterozygote advantage. I<br>
> thought there was a more specific term for that concept, but this states the<br>
> notion:<br>
><br>
> <a href="https://en.wikipedia.org/wiki/Heterozygote_advantage" rel="noreferrer" target="_blank">https://en.wikipedia.org/wiki/<wbr>Heterozygote_advantage</a><br>
><br>
> OK cool, so if we identify a bunch of these heterozygote advantages, then we<br>
> could use CRISPR to induce the mutant copy widely. Then when couples with<br>
> the mutation mate, a heterozygous embryo is chosen, then the result is a<br>
> healthier population (even though not one which can reproduce haphazardly.)<br>
<br>
</span>Nature will, over the long term, keep the gene frequencies in balance,<br>
while lagging the environment. Fiddling with gene frequencies without<br>
knowing more about the consequences is a risky business.<br>
<span class="HOEnZb"><font color="#888888"><br>
-rex<br>
--<br>
Theories: Four stages of acceptance: i) this is worthless nonsense; ii)<br>
this is an interesting, but perverse, point of view; iii) this is true,<br>
but quite unimportant; iv) I always said so. (J.B.S. Haldane, Journal of<br>
Genetics #58, 1963,p.464)<br>
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