<html><body><div id="edo-message"><div><div id="edo-sr">Very interesting!</div></div><div id="edo-sr"><br></div><div id="edo-sr">Are there any negative side effects Stuart </div><br></div><div id="edo-meta"></div><div id="edo-original"><div><br><br><blockquote type="cite" style="margin:1ex 0 0 0;border-left:1px #ccc solid;padding-left:0.5ex;"><div>On May 3, 2019 at 6:57 PM, <<a href="mailto:avant@sollegro.com">Stuart LaForge</a>> wrote:<br><br></div><div><pre><br>For those of you who might have missed it, the 2016 Nobel Prize in
<br>Medicine or Physiology went to Yoshinori Ohsumi for his work
<br>elucidating the mechanisms of autophagy. Briefly, autophagy is when
<br>cells are induced to digest their own damaged proteins to salvage
<br>amino acids for other purposes. It is evolutionarily a highly
<br>conserved process that we share with creatures as primitive as yeast.
<br>
<br>Here is a very good open access article in Cell about the process of
<br>autophagy and its role in health and disease:
<br>
<br>https://www.cell.com/cell/fulltext/S0092-8674(11)01276-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867411012761%3Fshowall%3Dtrue
<br>
<br>What I have learned is that when you don't eat for at least 16 hours
<br>or so, your body starts the process of autophagy where it digests worn
<br>out and damaged proteins in order to use the amino acids to synthesize
<br>new fully-functional proteins as well as synthesize glucose for your
<br>brain and your liver through the process of gluconeogenesis. Autophagy
<br>peaks between 24 and 48 hours and then declines to a slow and steady
<br>rate, once your body switches to burning your fat stores to obtain
<br>ketones to fuel your brain instead of glucose from amino acids.
<br>
<br>The upshot of this is that short fasts of between 24 and 48 hours do
<br>wonders for your health potentially reversing some of the effects of
<br>aging caused by the build up of worn out proteins and organelles in
<br>cells. I have been experimenting on myself by eating every other day
<br>both to both lose weight and to induce autophagy and I can't help but
<br>notice beneficial effects. My mood is improved, I feel sharper and
<br>more energetic with a general sense of well-being. Moreover, I have
<br>lost about 15 pounds in three weeks this way.
<br>
<br>On my fasting days, I try to get by on black morning coffee and a
<br>multivitamin and then water alone for the rest of the day. But if I
<br>get too hungry, then I eat a tablespoon of pure fat like butter, olive
<br>oil, or coconut oil. But I avoid eating any carbs or protein for the
<br>whole time.
<br>
<br>On my eating days, I pretty much eat anything I feel like eating,
<br>including dessert.
<br>
<br>For those of you who don't need to lose weight, I would just eat as
<br>much pure fat as you can stomach but nothing else, on one or two days
<br>a week so you can induce autophagy without losing any weight. Then
<br>make it a point to eat extra protein after the one or two fat only
<br>days are finished so you don't lose muscle mass.
<br>
<br>Anyways, water only fasting every other day is working for me so I
<br>thought I would share.
<br>
<br>Stuart LaForge
<br>
<br>
<br>
<br>
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<br></pre></div></blockquote></div></div></body></html>