<div dir="ltr"><div class="gmail_default" style="font-family:comic sans ms,sans-serif;font-size:small;color:#000000">Well,thanks. Now - where is the stuff? bill w</div></div><br><div class="gmail_quote"><div dir="ltr" class="gmail_attr">On Sun, Sep 8, 2019 at 10:30 AM Dan TheBookMan via extropy-chat <<a href="mailto:extropy-chat@lists.extropy.org">extropy-chat@lists.extropy.org</a>> wrote:<br></div><blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex"><div dir="auto">“Pulsing”<span style="background-color:rgba(255,255,255,0)"> usually means taking an escalating dose than dropping down to no dose and repeating. It can also mean just having long dose free periods, which seems what Dylan means here: he’s taking a weekly dose (as opposed to a daily one; I’m presuming it clears the body in far less than a week).</span><div><br></div><div>“Hitting” here means that the drug is simply having an impact. It reacts with both protein complexes and one is thought to be beneficial, the other harmful. Hence, he’s pulsing to get some beneficial effect whilst minimizing the harmful effect. (I don't think he used “hitting” here in any medical or technical sense. He was just being metaphorical.)<br><br><div id="gmail-m_-3826724946178271969AppleMailSignature" dir="ltr"><div style="line-height:normal"><div style="line-height:normal"><span style="line-height:20px;background-color:rgba(255,255,255,0)">Regards,</span></div><div style="line-height:normal"><span style="line-height:20px;background-color:rgba(255,255,255,0)"><br></span></div><div><div style="line-height:normal"><span style="line-height:20px;background-color:rgba(255,255,255,0)">Dan</span></div><div style="line-height:normal"><span style="line-height:20px;background-color:rgba(255,255,255,0)"> Sample my Kindle books at:</span></div><div style="line-height:normal"><p style="margin:0px;font-stretch:normal;font-size:12px;line-height:normal;font-family:Helvetica"><span style="font-size:12pt"><a href="http://author.to/DanUst" target="_blank">http://author.to/DanUst</a></span></p></div></div></div><div><div style="line-height:normal"></div></div></div><div dir="ltr"><br>On Sep 8, 2019, at 8:00 AM, William Flynn Wallace via extropy-chat <<a href="mailto:extropy-chat@lists.extropy.org" target="_blank">extropy-chat@lists.extropy.org</a>> wrote:<br><br></div><blockquote type="cite"><div dir="ltr"><div dir="ltr"><div class="gmail_default" style="font-family:"comic sans ms",sans-serif;font-size:small;color:rgb(0,0,0)"><span style="color:rgb(80,0,80);font-family:Arial,Helvetica,sans-serif">> I've been pulsing rapamycin for close to a year with no noticeable side effects. Taken once weekly, the idea is it maximizes hitting mTORC1 and minimizes hitting mTORC2. The literature indicates the anti aging effects are from the former and the negative side effects from the latter. dylan</span><br></div><div class="gmail_default" style="font-family:"comic sans ms",sans-serif;font-size:small;color:rgb(0,0,0)"><span style="color:rgb(80,0,80);font-family:Arial,Helvetica,sans-serif"><br></span></div><div class="gmail_default" style="font-size:small;color:rgb(0,0,0)"><span style="color:rgb(80,0,80)"><font face="comic sans ms, sans-serif">I Googled all these terms and determined that I needed a couple of course in biochemistry. first, what does 'pulsing' mean? Ditto 'hitting'. Second, where did you get your supplement? </font></span></div><div class="gmail_default" style="font-size:small;color:rgb(0,0,0)"><span style="color:rgb(80,0,80)"><font face="comic sans ms, sans-serif"><br></font></span></div><div class="gmail_default" style="font-size:small;color:rgb(0,0,0)"><span style="color:rgb(80,0,80)"><font face="comic sans ms, sans-serif">I am 77, in pretty good health, and practically never have any side effects of anything, so maybe I am a good candidate for this rapamycin. Please tell me all you can.</font></span></div><div class="gmail_default" style="font-size:small;color:rgb(0,0,0)"><span style="color:rgb(80,0,80)"><font face="comic sans ms, sans-serif"><br></font></span></div><div class="gmail_default" style="font-size:small;color:rgb(0,0,0)"><span style="color:rgb(80,0,80)"><font face="comic sans ms, sans-serif">Thanks! bill w</font></span></div></div></div></blockquote></div></div>_______________________________________________<br>
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