<div dir="ltr"><div class="gmail_default" style="font-family:comic sans ms,sans-serif;font-size:small;color:#000000">I have done a bit more research on berberine and am going to take metformin in the morning and berberine twice in the afternoon and evening. Taking all at one time not recommended. Will check blood sugars and let you know. I also found it on a list of 'gut healers' on Amazon. Also on a listd of pills for fat loss and dieting. </div><div class="gmail_default" style="font-family:comic sans ms,sans-serif;font-size:small;color:#000000"><br></div><div class="gmail_default" style="font-family:comic sans ms,sans-serif;font-size:small;color:#000000"> If you have anything bad to say about Examine.com let me know. Just ran across it. You might not know of it. Not a commercial site. No links to buy pills etc. Also ran across SAM-e. If you know anything about that I would be glad to hear about it. bill w</div></div><br><div class="gmail_quote"><div dir="ltr" class="gmail_attr">On Tue, Nov 19, 2019 at 10:18 AM Dylan Distasio via extropy-chat <<a href="mailto:extropy-chat@lists.extropy.org">extropy-chat@lists.extropy.org</a>> wrote:<br></div><blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex"><div dir="ltr">Unfortunately, I'm going to be somewhat unhelpful as I'm not entirely sure. I already take metformin myself (along with rapamycin) for the potential healthspan improvements (I'm not prediabetic/diabetic). I've actually toyed with the idea of adding berberine also but am focused on other items in the overall cocktail right now and the costs overall start to add up.<div><br></div><div>I don't think the combination would have any negative effect on pushing your blood sugar too low due to their mechanism of action (metformin amongst other things tamps down the creation of glucose by the liver (gluconeogenesis) but does not otherwise actually remove glucose from the blood, which makes it a very safe drug in that regard). </div><div><br></div><div>Just in case, I would keep an eye on your fasting blood glucose though, and I guess just monitor how you're feeling overall. Sorry that I don't have something more quantitative to suggest.</div><div><br></div><div>I would be very interested in hearing about your results though, and good luck with the continued fight against the prostate cancer.</div></div><br><div class="gmail_quote"><div dir="ltr" class="gmail_attr">On Tue, Nov 19, 2019 at 11:06 AM William Flynn Wallace via extropy-chat <<a href="mailto:extropy-chat@lists.extropy.org" target="_blank">extropy-chat@lists.extropy.org</a>> wrote:<br></div><blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex"><div dir="ltr"><div class="gmail_default" style="font-family:"comic sans ms",sans-serif;font-size:small;color:rgb(0,0,0)">Thanks! What side effects should I be looking for ? bill w</div></div><br><div class="gmail_quote"><div dir="ltr" class="gmail_attr">On Tue, Nov 19, 2019 at 9:51 AM Dylan Distasio via extropy-chat <<a href="mailto:extropy-chat@lists.extropy.org" target="_blank">extropy-chat@lists.extropy.org</a>> wrote:<br></div><blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex"><div dir="ltr">I would suggest being careful about noticing any side effects from combining it with metformin as they both target AMPK. Not arguing against combining them, but just be aware that they hit many of the same molecular pathways.</div><br><div class="gmail_quote"><div dir="ltr" class="gmail_attr">On Tue, Nov 19, 2019 at 10:42 AM William Flynn Wallace via extropy-chat <<a href="mailto:extropy-chat@lists.extropy.org" target="_blank">extropy-chat@lists.extropy.org</a>> wrote:<br></div><blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex"><div dir="ltr"><div class="gmail_default" style="font-family:"comic sans ms",sans-serif;font-size:small;color:rgb(0,0,0)">I have had it for over 20 years. A Gleason score of 4 means low aggressiveness. However, my PSA is going up. This article suggests that berberine can not only hinder prostate cancer but hold PSA steady. At $20 for three months I am adding it to my pile. Article also says that it controls blood sugar as well as metformin, which I also take. Hah! I might have to eat cake to keep my blood sugar up! Here is the link. I suggest you add People's Pharmacy to your email list and get their weekly bulletin. Highly educated people. They don't sell any drugs or supplements.</div><div class="gmail_default" style="font-family:"comic sans ms",sans-serif;font-size:small;color:rgb(0,0,0)"><br></div><div class="gmail_default" style="font-family:"comic sans ms",sans-serif;font-size:small;color:rgb(0,0,0)">bill w</div><div class="gmail_default" style="font-family:"comic sans ms",sans-serif;font-size:small;color:rgb(0,0,0)"><br></div><div class="gmail_default" style="font-family:"comic sans ms",sans-serif;font-size:small;color:rgb(0,0,0)"><a href="https://www.peoplespharmacy.com/articles/does-berberine-protect-against-prostate-cancer/?utm_source=The+People%27s+Pharmacy+Newsletter&utm_campaign=b59450b87d-MC_D_2019-11-19%26subscriber%3D1&utm_medium=email&utm_term=0_7300006d3c-b59450b87d-214968749&goal=0_7300006d3c-b59450b87d-214968749&mc_cid=b59450b87d&mc_eid=b9c6f5005a" target="_blank">https://www.peoplespharmacy.com/articles/does-berberine-protect-against-prostate-cancer/?utm_source=The+People%27s+Pharmacy+Newsletter&utm_campaign=b59450b87d-MC_D_2019-11-19%26subscriber%3D1&utm_medium=email&utm_term=0_7300006d3c-b59450b87d-214968749&goal=0_7300006d3c-b59450b87d-214968749&mc_cid=b59450b87d&mc_eid=b9c6f5005a</a><br></div></div>
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