<div dir="ltr"><div class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div dir="ltr"><font face="times new roman, serif" size="4">Dear friends</font><div><font face="times new roman, serif" size="4">I would like to bring to your attention the press release <span style="color:rgb(0,0,0)">by the International Society on Aging and Disease (ISOAD), </span><span style="color:rgb(0,0,0)">Shanghai</span><span style="color:rgb(0,0,0)"> </span><span style="color:rgb(0,0,0)">University</span><span style="color:rgb(0,0,0)">, </span><span style="color:rgb(0,0,0)">Chinese</span><span style="color:rgb(0,0,0)"> </span><span style="color:rgb(0,0,0)">Academy</span><span style="color:rgb(0,0,0)"> of </span><span style="color:rgb(0,0,0)">Medical Sciences & Peking Union Medical College, China:</span> <br><br style="color:rgb(28,30,33)"><span style="color:rgb(28,30,33)">A groundbreaking new therapeutic approach was developed and tested to improve outcome in patients suffering from novel coronavirus (COVID-19) pneumonia. The new technique involves intravenous transplantation of mesenchymal stem cells (MSCs) into the patients. It was successfully tested in 7 COVID-19 patients, in</span><span style="display:inline;color:rgb(28,30,33)"> Beijing YouAn Hospital, Capital Medical University, China. The results are published in the scientific journal <i>Aging and Disease</i>, entitled "Transplantation of ACE2- Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia" (free on line):</span></font><div><span style="display:inline;color:rgb(28,30,33)"><font face="times new roman, serif" size="4"><a href="http://www.aginganddisease.org/article/0000/2152-5250/ad-0-0-216.shtml" target="_blank">http://www.aginganddisease.org/article/0000/2152-5250/ad-0-0-216.shtml</a> <br><br>The study was conducted by a team led by Dr. Zhao, with Shanghai University and Chinese Academy of Medical Sciences & Peking Union Medical College, China.<br><br>MSCs could cure or significantly improve the functional outcomes of all the seven tested patients without observed adverse effects, contrary to 3 controls. The pulmonary function and symptoms of these seven patients were significantly improved after MSC transplantation. Among them, one severe and two common patients recovered and were discharged in 10 days after the treatment.<br><br>The presented evidence suggests that the therapeutic effects are based on the immunomodulatory capacity of mesenchymal stem cells (restoring the balance of the immune system). The coronavirus infection can stimulate a terrible cytokine storm in the lung, disrupting the balance of cytokines (signaling molecules of the immune system) such as IL-2, IL-6, IL-7, GSCF, IP10, MCP1, MIP1A and TNFα cytokines, followed by the edema, dysfunction of the air exchange, acute respiratory distress syndrome, acute cardiac injury and the secondary infection, which may lead to death. MSCs could inhibit the over-activation of the immune system and promote endogenous repair by improving the microenvironment, thus they could represent a safe and effective treatment for patients with COVID-19 pneumonia, especially for the patients in critically severe conditions.<br><br>Notably, the coronavirus-infected pneumonia is more likely to affect older individuals, especially older males, with comorbidities, resulting in their severe and even fatal respiratory diseases such as acute respiratory distress syndrome. In other words, aging appears to be the main risk factor for bad outcomes. However, the cure essentially depends on the patient's own immune system. When the overactivated immune system kills the virus, it produces a large number of inflammatory factors, leading to the severe cytokine storms. This suggests that the main reason for the organs damage may be the virus-induced cytokine storm. Older subjects may be much easier to be affected due to immunosenescence. The study showed remarkable recovery of the elderly patients thanks to restoring their immune function.<br><br>Thus, the study may have a broader significance, even beyond the treatment of the severe coronavirus disease. This study exemplifies that the general therapeutic improvement of the immune system in the elderly can improve outcome and survival, which may have more general relevance for other aging-related communicable diseases. Thus, this study may inspire and pave the way for further promising directions to investigate the connection between aging and disease, and to treat both communicable and non-communicable aging-related diseases.<br><br>See the full press release from the International Society on Aging and Disease (ISOAD)</font></span><div><span style="display:inline;color:rgb(28,30,33)"><font face="times new roman, serif" size="4"><a href="http://www.isoad.org/Data/View/744" target="_blank">http://www.isoad.org/Data/View/744</a> </font></span></div><div><span style="display:inline;color:rgb(28,30,33)"><font face="times new roman, serif" size="4">And the full free article</font></span></div><div><span style="display:inline;color:rgb(28,30,33)"><font face="times new roman, serif" size="4"><a href="http://www.aginganddisease.org/article/0000/2152-5250/ad-0-0-216.shtml" target="_blank">http://www.aginganddisease.org/article/0000/2152-5250/ad-0-0-216.shtml</a> </font></span></div><div><span style="display:inline;color:rgb(28,30,33)"><font face="times new roman, serif" size="4"><br></font></span></div><font face="times new roman, serif" size="4">Some press about this research:<br>In English <a href="http://www.china.org.cn/china/2020-03/07/content_75785868.htm" target="_blank">http://www.china.org.cn/china/2020-03/07/content_75785868.htm</a> <br>Romanian <a href="https://www.libertatea.ro/stiri/interviu-ilia-stambler-tratament-coronavirus-covid-19-2904173" target="_blank">https://www.libertatea.ro/stiri/interviu-ilia-stambler-tratament-coronavirus-covid-19-2904173</a><br></font><div><span style="display:inline;color:rgb(28,30,33)"><font face="times new roman, serif" size="4"><span style="color:rgb(34,34,34)">Korean <a href="https://www.fnnews.com/news/202003041842036630" target="_blank">https://www.fnnews.com/news/202003041842036630</a></span> </font></span></div><div></div><div><span style="display:inline;color:rgb(28,30,33)"></span></div><div><span style="display:inline;color:rgb(28,30,33)"><p class="MsoNormal" style="margin:0in 0in 0.0001pt;color:rgb(34,34,34);font-size:12pt;font-family:"Times New Roman""><br></p><p style="margin:0in 0in 0.0001pt;vertical-align:baseline;font-size:12pt;font-family:"Times New Roman""><span style="color:rgb(34,34,34);font-size:12pt">On Facebook</span><br></p><p class="MsoNormal" style="margin:0in 0in 0.0001pt;color:rgb(34,34,34);font-size:12pt;font-family:"Times New Roman""><a href="https://www.facebook.com/permalink.php?story_fbid=2853653751349033&id=763771300337299&__tn__=K-R" style="color:blue" target="_blank">https://www.facebook.com/permalink.php?story_fbid=2853653751349033&id=763771300337299&__tn__=K-R</a></p><p class="MsoNormal" style="margin:0in 0in 0.0001pt;color:rgb(34,34,34);font-size:12pt;font-family:"Times New Roman""><span style="font-size:12pt">Linkedin</span></p><p class="MsoNormal" style="margin:0in 0in 0.0001pt;color:rgb(34,34,34);font-size:12pt;font-family:"Times New Roman""><a href="https://www.linkedin.com/groups/13504310/" style="color:blue" target="_blank">https://www.linkedin.com/groups/13504310/</a></p><p class="MsoNormal" style="margin:0in 0in 0.0001pt;color:rgb(34,34,34);font-size:12pt;font-family:"Times New Roman""><a href="https://www.linkedin.com/pulse/new-therapeutic-approach-improves-outcome-patients-ilia-stambler/" style="color:blue;font-size:12pt" target="_blank">https://www.linkedin.com/pulse/new-therapeutic-approach-improves-outcome-patients-ilia-stambler/</a></p><p class="MsoNormal" style="margin:0in 0in 0.0001pt;color:rgb(34,34,34);font-size:12pt;font-family:"Times New Roman"">Twitter</p><p class="MsoNormal" style="margin:0in 0in 0.0001pt;color:rgb(34,34,34);font-size:12pt;font-family:"Times New Roman""><a href="https://twitter.com/isoad3/status/1235637338333560832" style="color:blue;font-size:12pt" target="_blank">https://twitter.com/isoad3/status/1235637338333560832</a></p></span><br clear="all"><div>Ilia Stambler</div><div>Outreach coordinator. International Society on Aging and Disease</div><div><a href="http://www.isoad.org/" target="_blank">http://www.isoad.org/</a> <br></div><div><br></div></div></div></div></div></div></div></div><div><br></div>-- <br><div dir="ltr" class="gmail_signature" data-smartmail="gmail_signature"><div dir="ltr"><div><div dir="ltr"><div><div dir="ltr"><div><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><p style="margin:0in 0in 0.0001pt;background-image:initial;background-repeat:initial"><span style="font-family:Arial"><font size="1">Ilia Stambler, PhD</font></span></p><p style="margin:0in 0in 0.0001pt;background-image:initial;background-repeat:initial"><span style="color:rgb(51,51,51);font-family:"Helvetica Neue",Helvetica,Arial,sans-serif"><font size="1"><br></font></span></p><p style="margin:0in 0in 0.0001pt;background-image:initial;background-repeat:initial"><font size="1"><span style="color:rgb(51,51,51);font-family:"Helvetica Neue",Helvetica,Arial,sans-serif">Director of Research and Development. Shmuel Harofe Geriatric Medical Center, Beer Yaakov, Israel, Affiliated to Sackler School of Medicine, Tel-Aviv University </span><a href="http://www.shmuelh.org.il/" target="_blank">http://www.shmuelh.org.il/</a> <br></font></p>
<p style="margin:0in 0in 0.0001pt;background-image:initial;background-repeat:initial"><span style="font-family:Arial"><font size="1"><br></font></span></p><p style="margin:0in 0in 0.0001pt;background-image:initial;background-repeat:initial"><font size="1"><span style="font-family:Arial">Chair. Israeli
Longevity Alliance / CSO. </span>Vetek (Seniority) – The Movement for Longevity and Quality of Life (Israel)<span style="font-family:Arial"> </span><font color="#0000ee" face="Arial"><u><a href="http://www.longevityisrael.org/" target="_blank">http://www.longevityisrael.org/</a></u></font></font></p>
<p style="margin:0in 0in 0.0001pt;background-image:initial;background-repeat:initial"><font size="1"><span style="font-family:Arial">Board member. International Longevity Alliance </span><a href="http://www.longevityalliance.org/" target="_blank">http://www.longevityalliance.org/</a> Board member. International Society on Aging and Disease <a href="http://www.isoad.org/" target="_blank">http://www.isoad.org</a> Fellow, Policy Director. Global Healthspan Policy Institute <a href="https://healthspanpolicy.org/" target="_blank">https://healthspanpolicy.org/</a></font></p>
<p style="margin:0in 0in 0.0001pt;background-image:initial;background-repeat:initial"><font size="1"><span style="font-family:Arial">Author. Longevity
History.<span> </span><i>A History of
Life-Extensionism in the Twentieth Century </i>; </span><i>Longevity Promotion:
Multidisciplinary Perspectives </i><span style="font-family:Arial;color:blue"><a href="http://longevityhistory.com/" target="_blank"><span lang="DE">http://longevityhistory.com</span></a></span></font></p>
<p style="margin:0in 0in 0.0001pt;background-image:initial;background-repeat:initial"><span lang="DE" style="font-family:Arial"><font size="1"> </font></span></p>
<p style="margin:0in 0in 0.0001pt;background-image:initial;background-repeat:initial"><font size="1"><span lang="DE" style="font-family:Arial">Email:<span> </span></span><span style="font-family:Arial"><a href="mailto:ilia.stambler@gmail.com" target="_blank"><span lang="DE" style="color:rgb(17,85,204)">ilia.stambler@gmail.com</span></a></span><span lang="DE" style="font-family:Arial"></span></font></p>
<p style="margin:0in 0in 0.0001pt;background-image:initial;background-repeat:initial"><span lang="DE" style="font-family:Arial"><font size="1">Tel: 972-3-961-4296 / 0522-283-578</font></span></p><p style="margin:0in 0in 0.0001pt;background-image:initial;background-repeat:initial"><span lang="DE" style="font-family:Arial"><font size="1">Skype: iliastam</font></span></p>
<p style="margin:0in 0in 0.0001pt;background-image:initial;background-repeat:initial"><span lang="DE" style="font-family:Arial"><font size="1">Rishon Lezion. Israel</font><br><span style="font-size:10pt"></span></span></p></div></div></div></div></div></div></div></div></div></div></div></div></div>