<div dir="ltr"><div class="gmail_default" style="font-family:comic sans ms,sans-serif;font-size:small;color:#000000">You must know things I don't about 23 and me. How do you know the surveys are failures? bill w</div></div><br><div class="gmail_quote"><div dir="ltr" class="gmail_attr">On Sat, Apr 4, 2020 at 11:44 AM spike jones via extropy-chat <<a href="mailto:extropy-chat@lists.extropy.org">extropy-chat@lists.extropy.org</a>> wrote:<br></div><blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex"><div lang="EN-US"><div class="gmail-m_-7474592757638084830WordSection1"><p class="MsoNormal"><u></u> <u></u></p><p class="MsoNormal"><u></u> <u></u></p><p class="MsoNormal"><b>From:</b> extropy-chat <<a href="mailto:extropy-chat-bounces@lists.extropy.org" target="_blank">extropy-chat-bounces@lists.extropy.org</a>> <b>On Behalf Of </b>William Flynn Wallace via extropy-chat<br><br><span style="font-size:12pt;font-family:"Comic Sans MS";color:black"><u></u><u></u></span></p><div><div><p class="MsoNormal"><span style="font-size:12pt;font-family:"Comic Sans MS";color:black"><u></u> <u></u></span></p></div><div><p class="MsoNormal"><span style="font-size:12pt;font-family:"Comic Sans MS"">>…<span style="color:black">I just have no feelings for 3 cousins - there must be hundreds or thousands of them</span>…<u></u><u></u></span></p><p class="MsoNormal"><span style="font-size:12pt;font-family:"Comic Sans MS""><u></u> <u></u></span></p><p class="MsoNormal"><span style="font-size:12pt;font-family:"Comic Sans MS"">Ja.<u></u><u></u></span></p><p class="MsoNormal"><span style="font-size:12pt;font-family:"Comic Sans MS""><u></u> <u></u></span></p><p class="MsoNormal"><span style="font-size:12pt;font-family:"Comic Sans MS"">>…<span style="color:black"> I don't know what you get out of it, Spike, but I hope you get all you want</span>…<span style="color:black"><u></u><u></u></span></span></p></div><div><p class="MsoNormal"><span style="font-size:12pt;font-family:"Comic Sans MS";color:black">bill w<u></u><u></u></span></p><p class="MsoNormal"><u></u> <u></u></p><p class="MsoNormal">I want to see if we can succeed where 23&Me failed.<u></u><u></u></p><p class="MsoNormal"><u></u> <u></u></p><p class="MsoNormal">The idea behind 23 was get a bunch of people to do DNA tests, group them, have them fill out surveys about their health, see if there are certain conditions that run in certain DNA-clades.<u></u><u></u></p><p class="MsoNormal"><u></u> <u></u></p><p class="MsoNormal">Good idea, but I would call it generally a failure for a reason we mighta anticipated: surveys by users on their own health is some of the lowest quality data there is. Reason: plenty of people, really most people, don’t really know what is wrong with them and don’t know what is right with them.<u></u><u></u></p><p class="MsoNormal"><u></u> <u></u></p><p class="MsoNormal">For instance… plenty of people imagine they have conditions they do not have. Or they imagine they have conditions that they keep under control by drinking four drops of {grapefruit seed extract, vitamin x, supply condition and treatment} but they don’t have that condition, never did. <u></u><u></u></p><p class="MsoNormal"><u></u> <u></u></p><p class="MsoNormal">Populations don’t know what is right with them either, because they aren’t aware of that condition at all, they never heard of it. They miss some signals, such as a group relative immunity to something that rips a different DNA group elsewhere. For instance: suppose an Eastern European DNA group doesn’t ever get acne during adolescence. We already know some teens never get that, but it would be easy to miss if they is a genetic component in there somewhere. They can ask about it on the survey and still miss it, but I realized long after the fact that I went thru those years and never did have more than a very slight case of that, while others were torn up with it. Something like that would be easy to miss.<u></u><u></u></p><p class="MsoNormal"><u></u> <u></u></p><p class="MsoNormal">Well, OK then, the 23 experiment may have been a general failure, but the idea was good. <u></u><u></u></p><p class="MsoNormal"><u></u> <u></u></p><p class="MsoNormal">Now suppose we can put together some kind of database which allows software to scour through and look for signals. And suppose that over time, accurate DNA genealogical information does accumulate, along with reliable information on the location of the roots back when people travelled less than the do now and hundreds of generations went by with not a lot of DNA coming in or going out. We find better ways to map out all that, then we try the 23&Me experiment again, but this time with more and better medical diagnostics, more and better DNA-genealogy and so forth.<u></u><u></u></p><p class="MsoNormal"><u></u> <u></u></p><p class="MsoNormal">BillW, regarding all I want: I am setting up a database to collect groups of descendants of a common ancestor. Then we can look for medical conditions within those groups, searching for stuff that might be out of the normal range.<u></u><u></u></p><p class="MsoNormal"><u></u> <u></u></p><p class="MsoNormal">When you think about it, evolutionary psychology is kinda sorta that same idea, only that looks at behaviors, rather than medical conditions or physical traits. I will leave that to the experts, while I do my thing: looking for stuff like a particular oddball medical condition that seems more prevalent in a group for instance.<u></u><u></u></p><p class="MsoNormal"><u></u> <u></u></p><p class="MsoNormal">spike<u></u><u></u></p></div></div></div></div>_______________________________________________<br>
extropy-chat mailing list<br>
<a href="mailto:extropy-chat@lists.extropy.org" target="_blank">extropy-chat@lists.extropy.org</a><br>
<a href="http://lists.extropy.org/mailman/listinfo.cgi/extropy-chat" rel="noreferrer" target="_blank">http://lists.extropy.org/mailman/listinfo.cgi/extropy-chat</a><br>
</blockquote></div>