<div dir="ltr"><blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex">I can state from such personal knowledge that making this virus in a lab is beyond the state of the art</blockquote><div>Please elaborate?</div><div><br></div><div><br></div></div><br><div class="gmail_quote"><div dir="ltr" class="gmail_attr">On Wed, Apr 15, 2020 at 7:06 AM Keith Henson via extropy-chat <<a href="mailto:extropy-chat@lists.extropy.org">extropy-chat@lists.extropy.org</a>> wrote:<br></div><blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex"><a href="mailto:robot@ultimax.com" target="_blank">robot@ultimax.com</a> wrote:<br>
<br>
> Not that I think anybody will respond, because there never is, but:<br>
<br>
Not getting a reply to a post is usual for me. There are two main<br>
reasons, the readers didn't understand it or it was so clear that<br>
people didn't find anything to respond to.<br>
<br>
< Spike's scenario doesn't explain the crossover event.<br>
<br>
Agree. But I have followed gene engineering for decades. I can state<br>
from such personal knowledge that making this virus in a lab is beyond<br>
the state of the art. Not really far beyond the state of the art but<br>
it is at least 5 years out and more likely ten years. The showstopper<br>
would be designing the entry protein.<br>
<br>
> SARS-CoV-2 is not 100% bat content. Mostly it is -- 80%?? The balance,<br>
20%??, came from some other mammal. Pangolin (an Asian anteater, looks<br>
a lot like an armadillo) is the thinking, but, whatever.<br>
<br>
The path that seems most likely is that the virus made the jump from<br>
bats to pangolins some time ago. I don't remember where I saw it, but<br>
COVID-19 was found to be 99% similar to a coronavirus from pangolins.<br>
<br>
snip influenza data<br>
<br>
> So where did that crossover happen? /in vivo/ or /in vitro/?<br>
<br>
Flu is very different from coronavirus. It does not swap pieces of<br>
its genome with other viruses like flu does. The first human who got<br>
it was just unlucky that it was able to infect him. The second human<br>
was unlucky that the virus was able to infect from the first.<br>
<br>
It certainly could be worse. The related MERS virus kills about 70%<br>
of the people it infects. That's the pandemic that could cut the<br>
world population by half.<br>
<br>
As it is, too many people being sick at the same time is starting to<br>
have effects on the food supply.<br>
<br>
Keith<br>
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</blockquote></div>