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</o:shapelayout></xml><![endif]--></head><body lang=EN-US link="#0563C1" vlink="#954F72"><div class=WordSection1><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal>Those of you who were at the Extro4 BioTech Futures conference at Berkeley in 1999 perhaps remember a talk about DNA editing at the cell level.<o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal>At a particularly dramatic moment as the keynote speaker was giving a lecture on the topic, our own Robert Bradbury stood and shouted “THAT’S NOT TRUE!”<o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal>Those two argued as the audience listened, with Robert arguing that in-vitro gene editing will someday be possible, while the keynote speaker was adamant that it would never be done.<o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal>Robert was staying at my house for that event, so we had time to discuss it. I didn’t understand, being a space guy, not a bio guy. Robert was arguing that this would someday be possible:<o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><a href="https://www.healthline.com/health-news/crispr-gene-editing-used-for-the-first-time-inside-a-persons-body">https://www.healthline.com/health-news/crispr-gene-editing-used-for-the-first-time-inside-a-persons-body</a><o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal>Robert has been gone over 9 yrs now. I miss him like he left us yesterday.<o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><a href="http://www.sentientdevelopments.com/2011/03/remembering-robert-bradbury.html">http://www.sentientdevelopments.com/2011/03/remembering-robert-bradbury.html</a><o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal>This is a paper that was the preliminary to a follow-on Matrioshka Brain paper he and I were working on between 2000 and about 2006. I was doing the orbit mechanics and thermo stuff, he was doing the computing stuff.<o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial",sans-serif;color:#444444;background:white'><a href="http://www.gwern.net/docs/1999-bradbury-matrioshkabrains.pdf">http://www.gwern.net/docs/1999-bradbury-matrioshkabrains.pdf</a><o:p></o:p></span></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal>spike<o:p></o:p></p></div></body></html>