<div dir="ltr"><div class="gmail_default" style="font-family:comic sans ms,sans-serif;font-size:large;color:#000000"><span style="color:rgb(34,34,34);font-family:Arial,Helvetica,sans-serif;font-size:small">Yes, being in the first wave of gene therapy patients will probably be bad, humans tend to fuck things up will</span><br></div><div class="gmail_default" style="font-family:comic sans ms,sans-serif;font-size:large;color:#000000"><span style="color:rgb(34,34,34);font-family:Arial,Helvetica,sans-serif;font-size:small"><br></span></div><div class="gmail_default" style="font-size:large;color:rgb(0,0,0)"><span style="color:rgb(34,34,34);font-size:small"><font face="comic sans ms, sans-serif">How many scientific discoveries occurred the very first time something was tried? I'd say probably none. Every success rests atop a mountain of failures. bill w</font></span></div></div><br><div class="gmail_quote"><div dir="ltr" class="gmail_attr">On Wed, Aug 25, 2021 at 2:39 AM Will Steinberg via extropy-chat <<a href="mailto:extropy-chat@lists.extropy.org">extropy-chat@lists.extropy.org</a>> wrote:<br></div><blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex"><div dir="auto">Yes, being in the first wave of gene therapy patients will probably be bad, humans tend to fuck things up</div><br><div class="gmail_quote"><div dir="ltr" class="gmail_attr">On Wed, Aug 25, 2021, 12:37 AM Darin Sunley via extropy-chat <<a href="mailto:extropy-chat@lists.extropy.org" target="_blank">extropy-chat@lists.extropy.org</a>> wrote:<br></div><blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex"><div dir="ltr">That's really cool, but discovering the mechanism is one thing. Building a working therapy to use it is another thing entirely. And then convincing the population at large that it's safe and reliable - that'll be the hardest trick of all. Popular trust in the institution of public health policy is at an all-time low, and they've no one to blame but themselves.<div><br></div><div>The politicization of the discourse around the known side-effects of the mRNA vaccines being currently marketed has probably set genetic therapy as a field back 30 years or more.</div></div><br><div class="gmail_quote"><div dir="ltr" class="gmail_attr">On Tue, Aug 24, 2021 at 6:42 PM John Grigg via extropy-chat <<a href="mailto:extropy-chat@lists.extropy.org" rel="noreferrer" target="_blank">extropy-chat@lists.extropy.org</a>> wrote:<br></div><blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex"><div dir="ltr"><p style="box-sizing:border-box;font-family:proxima-nova,sans-serif;line-height:26px;margin-top:0px;margin-bottom:26px"><font size="4">"Enter SEND. The new delivery platform, <a href="https://science.sciencemag.org/content/373/6557/882" style="box-sizing:border-box;background-color:transparent;color:rgb(237,102,41);text-decoration-line:none" rel="noreferrer" target="_blank">described in</a> <i style="box-sizing:border-box">Science</i>, dazzles with its sheer ingenuity. Rather than relying on foreign carriers, SEND (<b style="box-sizing:border-box">s</b>elective <b style="box-sizing:border-box">e</b>ndogenous e<b style="box-sizing:border-box">n</b>capsidation for cellular <b style="box-sizing:border-box">d</b>elivery) commandeers human proteins to make delivery vehicles that shuttle in new genetic elements. In a series of tests, the team embedded RNA cargo and CRISPR components inside cultured cells in a dish. The cells, acting as packing factories, used human proteins to encapsulate the genetic material, forming tiny balloon-like vessels that can be collected as a treatment.</font></p><p style="box-sizing:border-box;font-family:proxima-nova,sans-serif;line-height:26px;margin-top:0px;margin-bottom:26px"><font size="4">Even weirder, the source of these proteins relies on viral genes domesticated eons ago by our own genome through evolution. Because the proteins are essentially human, they’re unlikely to trigger our immune system.</font></p><p style="box-sizing:border-box;font-family:proxima-nova,sans-serif;line-height:26px;margin-top:0px;margin-bottom:26px"><font size="4">Although the authors only tried one packaging system, far more are hidden in our genomes. “That’s what’s so exciting,” said study author Dr. Michael Segel, adding that the system they used isn’t unique; “There are probably other RNA transfer systems in the human body that can also be harnessed for therapeutic purposes.”</font></p><div><font size="4"><a href="https://singularityhub.com/2021/08/24/surprise-our-bodies-have-been-hiding-a-trojan-horse-for-gene-therapy/" rel="noreferrer" target="_blank">https://singularityhub.com/2021/08/24/surprise-our-bodies-have-been-hiding-a-trojan-horse-for-gene-therapy/</a></font><br></div></div>
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