<div dir="auto"><div><div class="gmail_quote gmail_quote_container"><div dir="ltr" class="gmail_attr">On Mon, Jan 12, 2026, 5:23 AM Rafal Smigrodzki via extropy-chat <<a href="mailto:extropy-chat@lists.extropy.org">extropy-chat@lists.extropy.org</a>> wrote:<br></div><blockquote class="gmail_quote" style="margin:0 0 0 .8ex;border-left:1px #ccc solid;padding-left:1ex"><div dir="ltr"><div>I briefly perused recent posts to ExI and I must admit to a certain sense of tedium... so much talk about the one whom I will not name, and about the wonders of socialism, so few discussions of... interesting stuff.</div></div></blockquote></div></div><div dir="auto"><br></div><div dir="auto">I'm not sure I could get much useful discussion of the projects I'm working on here. Discussion derails into how nothing with a time horizon beyond a few years can possibly matter (as if the Singularity, even assuming it happens that fast, can rewrite known physics - and that's when the reason is not political doom and gloom), or there just isn't interest here (trying to construct what would be one of the largest buildings in North Carolina to help address local housing needs and urbanization pains is, admittedly, primarily of local interest).</div><div dir="auto"><br></div><div dir="auto">Even Keith's trash-to-fuel project did not get much discussion.</div><div dir="auto"><br></div><div dir="auto"></div><div dir="auto"><div class="gmail_quote gmail_quote_container"><blockquote class="gmail_quote" style="margin:0 0 0 .8ex;border-left:1px #ccc solid;padding-left:1ex"><div dir="ltr"><div>Have you heard that 75% of all so-called sporadic Alzheimer's disease is actually caused by mutations in just one gene (and it's not amyloid)? It's ApoE. That's an amazing development, really puts into perspective how misguided most AD research was in the past 50 years.</div></div></blockquote></div></div><div dir="auto"><br></div><div dir="auto">I'm waiting for an analysis to see how the research could have gone so far off track for 50 years, and how that possibility can be identified in other fields of research before 50 years are spent - and how we know for sure that this solution is the correct one.</div><div dir="auto"><div class="gmail_quote gmail_quote_container"><blockquote class="gmail_quote" style="margin:0 0 0 .8ex;border-left:1px #ccc solid;padding-left:1ex">
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