[Paleopsych] Introns: the "junk DNA" that controls gene expression
Steve Hovland
shovland at mindspring.com
Sun Apr 3 16:45:37 UTC 2005
http://post.queensu.ca/~forsdyke/introns.htm
In the 1960s non-bacterial (eukaryotic) ribosomal RNAs (rRNAs) were found
to be synthesized as a long precursor RNA which was subsequently processed
by the removal of apparently functionless internal "spacer" sequences.
Since bacterial (prokaryotic) rRNAs were more compactly organized, it was
reasonable to ask whether the first rRNAs to evolve had the spacer
sequences, which subsequently decreased in prokaryotes, or whether the
spacer sequences were later acquired in eukaryotes.
In the 1960s a similar processing was found to apply to eukaryotic
precursor messenger RNAs (pre-mRNAs; Scherrer et al. 1970). In the mid
1970s it was found that the some of the internal sequences interrupted the
protein-encoding part of the corresponding mRNAs. The internal sequences
which were removed were named "introns", and what remained in the processed
mRNA constituted the "exons". Since the phenomenon had already been
described for rRNA it should have been no big deal to find that it also
applied to other RNAs, but many, including the author of these pages, were
surprised that protein-encoding regions were interrupted. The same
questions remained.
Google: http://www.google.com/search?hl=en&q=introns&btnG=Google+Search
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