[Paleopsych] Post-transcription modification of DNA etc

Steve Hovland shovland at mindspring.com
Sun Apr 3 18:25:40 UTC 2005


Biochemistry of Nucleic Acids
Class: BioC-507
Coordinators: Drs. Mukund Modak
Instructors: Drs. M. Modak, F. Coffman, N. Kaushik, C. Suzuki, V. Pandey, 
R. Howells, C. Lutz, M. Rogers, S. Kotenko, J. Wilusz, H. Jakubowski, M. 
Goldman, S. Gunnery, and M. B. Mathews.
Prerequisite: Completion of the 1st year of Core Course
Time: Fall semester (September - February)
Course Description:
The objective of this course is to comprehend the biochemical mechanism by 
which protein and RNA factors regulate the structure and function of 
nucleic acids in diverse organism including viruses and higher eukaryotes. 
Main format of the course is to critically review the past and current 
literature on the 7 selected topics. They include (1) historical 
perspective, (2) DNA topology, (3) chromatin structure, (4) DNA replication 
(5) reverse transcription, (6) transcription, (7) post-transcription 
modification, (8) translation. Topics 1-3 will discuss the physical and 
chemical property of DNA and the higher order organization of DNA. Topics 
4-5 will cover the molecular scheme of DNA and RNA replication and key 
enzymes such as DNA polymerases and reverse transcriptases. Topic 6 will 
review the enzymatic basis of transcription activation and repression, 
discussing RNA polymerases, activators, and repressors. Topic 7 will cover 
the mechanism of pre-mRNA splicing and polyadenylation, protein factors 
modifying mRNA such as capping, decapping, and editing enzyme, and dsRNA 
interference (RNAi). Finally, topic 8 will discuss the principle of 
translational control, major players in translation such as tRNA, ssRSs, 
and Se-Cys-tRNA, and the molecular basis of translation, comparatively 
reviewing scanning, IRES, and shunting mechanisms.


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