[Paleopsych] Post-transcription modification of DNA etc
shovland at mindspring.com
Sun Apr 3 18:25:40 UTC 2005
Biochemistry of Nucleic Acids
Coordinators: Drs. Mukund Modak
Instructors: Drs. M. Modak, F. Coffman, N. Kaushik, C. Suzuki, V. Pandey,
R. Howells, C. Lutz, M. Rogers, S. Kotenko, J. Wilusz, H. Jakubowski, M.
Goldman, S. Gunnery, and M. B. Mathews.
Prerequisite: Completion of the 1st year of Core Course
Time: Fall semester (September - February)
The objective of this course is to comprehend the biochemical mechanism by
which protein and RNA factors regulate the structure and function of
nucleic acids in diverse organism including viruses and higher eukaryotes.
Main format of the course is to critically review the past and current
literature on the 7 selected topics. They include (1) historical
perspective, (2) DNA topology, (3) chromatin structure, (4) DNA replication
(5) reverse transcription, (6) transcription, (7) post-transcription
modification, (8) translation. Topics 1-3 will discuss the physical and
chemical property of DNA and the higher order organization of DNA. Topics
4-5 will cover the molecular scheme of DNA and RNA replication and key
enzymes such as DNA polymerases and reverse transcriptases. Topic 6 will
review the enzymatic basis of transcription activation and repression,
discussing RNA polymerases, activators, and repressors. Topic 7 will cover
the mechanism of pre-mRNA splicing and polyadenylation, protein factors
modifying mRNA such as capping, decapping, and editing enzyme, and dsRNA
interference (RNAi). Finally, topic 8 will discuss the principle of
translational control, major players in translation such as tRNA, ssRSs,
and Se-Cys-tRNA, and the molecular basis of translation, comparatively
reviewing scanning, IRES, and shunting mechanisms.
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