[Paleopsych] Testing Darwin: Digital Life

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Testing Darwin: Digital Life

----- Forwarded message from Giu1i0 Pri5c0 <pgptag at gmail.com> -----
From: Giu1i0 Pri5c0 <pgptag at gmail.com>
Date: Mon, 14 Feb 2005 16:38:19 +0100
Subject: [>Htech] TESTING DARWIN - Digital Life

If you want to find alien life-forms, hold off on booking that trip to
the moons of Saturn. You may only need to catch a plane to East
Lansing, Michigan.
The aliens of East Lansing are not made of carbon and water. They have
no DNA. Billions of them are quietly colonizing a cluster of 200
computers in the basement of the Plant and Soil Sciences building at
Michigan State University. To peer into their world, however, you have
to walk a few blocks west on Wilson Road to the engineering department
and visit the Digital Evolution Laboratory. Here you'll find a crew of
computer scientists, biologists, and even a philosopher or two gazing
at computer monitors, watching the evolution of bizarre new
These are digital organisms-strings of commands-akin to computer
viruses. Each organism can produce tens of thousands of copies of
itself within a matter of minutes. Unlike computer viruses, however,
they are made up of digital bits that can mutate in much the same way
DNA mutates. A software program called Avida allows researchers to
track the birth, life, and death of generation after generation of the
digital organisms by scanning columns of numbers that pour down a
computer screen like waterfalls.

If you want to find alien life-forms, hold off on booking that trip to the
moons of Saturn. You may only need to catch a plane to East Lansing,

The aliens of East Lansing are not made of carbon and water. They have no
DNA. Billions of them are quietly colonizing a cluster of 200computers in the
basement of the Plant and Soil Sciences building at Michigan State
University. To peer into their world, however, you have to walk a few blocks
west on Wilson Road to the engineering department and visit the Digital
Evolution Laboratory. Here you'll find a crew of computer scientists,
biologists, and even a philosopher or two gazing at computer monitors,
watching the evolution of bizarre new life-forms.

These are digital organisms-strings of commands-akin to computer viruses.
Each organism can produce tens of thousands of copies of itself within a
matter of minutes. Unlike computer viruses, however, they are made up of
digital bits that can mutate in much the same way DNA mutates. A software
program called Avida allows researchers to track the birth, life, and death
of generation after generation of the digital organisms by scanning columns
of numbers that pour down a computer screen like waterfalls.

After more than a decade of development, Avida's digital organisms are now
getting close to fulfilling the definition of biological life. .More and more
of the features that biologists have said were necessary for life we can
check off,. says Robert Pennock, a philosopher at Michigan State and a member
of the Avida team. .Does this, does that, does this. Metabolism? Maybe not
quite yet, but getting pretty close..

One thing the digital organisms do particularly well is evolve.. Avida is not
a simulation of evolution; it is an instance of it,. Pennock says. .All the
core parts of the Darwinian process are there. These things replicate, they
mutate, they are competing with one another. The very process of natural
selection is happening there. If that's central to the definition of life,
then these things count..

It may seem strange to talk about a chunk of computer code in the same way
you talk about a cherry tree or a dolphin. But the more biologists think
about life, the more compelling the equation becomes. Computer programs and
DNA are both sets of instructions. Computer programs tell a computer how to
process information, while DNA instructs a cell how to assemble proteins.

The ultimate goal of the instructions in DNA is to make new organisms that
contain the same genetic instructions. .You could consider a living organism
as nothing more than an information channel, where it's transmitting its
genome to its offspring,. says Charles Ofria, director of the Digital
Evolution Laboratory. .And the information stored in the channel is how to
build a new channel.. So a computer program that contains instructions for
making new copies of itself has taken a significant step toward life.

A cherry tree absorbs raw materials and turns them into useful things. In
goes carbon dioxide, water, and nutrients. Out comes wood, cherries, and
toxins to ward off insects. A computer program works the same way. Consider a
program that adds two numbers. The numbers go in like carbon dioxide and
water, and the sum comes out like a cherry tree.

In the late 1990s Ofria's former adviser, physicist Chris Adami of Caltech,
set out to create the conditions in which a computer program could evolve the
ability to do addition. He created some primitive digital organisms and at
regular intervals presented numbers to them. At first they could do nothing.
But each time a digital organism replicated, there was a small chance that
one of its command lines might mutate. On a rare occasion, these mutations
allowed an organism to process one of the numbers in a simple way. An
organism might acquire the ability simply to read a number, for example, and
then produce an identical output.

Adami rewarded the digital organisms by speeding up the time it took them to
reproduce. If an organism could read two numbers at once, he would speed up
its reproduction even more. And if they could add the numbers, he would give
them an even bigger reward. Within six months, Adami's organisms were
addition whizzes. .We were able to get them to evolve without fail,. he says.
But when he stopped to look at exactly how the organisms were adding numbers,
he was more surprised. .Some of the ways were obvious, but with others I'd
say, 'What the hell is happening?' It seemed completely insane..

On a trip to Michigan State, Adami met microbiologist Richard Lenski, who
studies the evolution of bacteria. Adami later sent Lenski a copy of the
Avida software so he could try it out for himself. On a Friday, Lenski loaded
the program into his computer and began to create digital worlds. By Monday
he was tempted to shut down his lab and dedicate himself to Avida. .It just
had the smell of life,. says Lenski.

It also mirrored Lenski's own research. Since 1988 he has been running the
longest continuous experiment in evolution. He began with a single
bacterium-Escherichia coli-and used its offspring to found 12separate
colonies of bacteria that he nurtured on a meager diet of glucose, which
creates a strong incentive for the evolution of new ways to survive. Over the
past 17years, the colonies have passed through35,000 generations. In the
process, they've become one of the clearest demonstrations that natural
selection is real. All 12 colonies have evolved to the point at which the
bacteria can replicate almost twice as fast as their ancestors. At the same
time, the bacterial cells have gotten twice as big. Surprisingly, these
changes didn't unfold in a smooth, linear process. Instead, each colony
evolved in sudden jerks, followed by hundreds of generations of little
change, followed by more jerks.

Similar patterns occur in the evolution of digital organisms in Avida. So
Lenski set up digital versions of his bacterial colonies and has been
studying them ever since. He still marvels at the flexibility and speed of
Avida, which not only allow him to alter experimental conditions with a few
keystrokes but also to automatically record every mutation in every organism.
.In an hour I can gather more information than we had been able to gather in
years of working on bacteria,. Lenski say.. Avida just spits data at you..

With this newfound power, the Avida team is putting Darwin to the test in a
way that was previously unimaginable. Modernevolutionary biologists have a
wealth of fossils to study, and they can compare the biochemistry and genes
of living species. But they can't look at every single generation and every
single gene that separates a bird, for example, from its two-legged dinosaur
ancestors. By contrast, Avida makes it possible to watch the random mutation
and natural selection of digital organisms unfold over millions of
generations. In the process, it is beginning to shed light on some of the
biggest questions of evolution.


If life today is the result of evolution by natural selection, Darwin
realized, then even the most complex systems in biology must have emerged
gradually from simple precursors, like someone crossing a river using
stepping-stones. But consider the human eye, which is made of many different
parts-lens, iris, jelly, retina, optic nerve-and will not work if even one
part is missing. If the eye evolved in a piecemeal fashion, how was it of any
use to our ancestors? Darwin argued that even a simpler version of today's
eyes could have helped animals survive. Early eyes might have been nothing
more than a patch of photosensitive cells that could tell an animal if it was
in light or shadow. If that patch then evolved into a pit, it might also have
been able to detect the direction of the light. Gradually, the eye could have
taken on new functions, until at last it could produce full-blown images.
Even today, you can find these sorts of proto-eyes in flatworms and other
animals. Darwin declared that the belief that natural selection cannot
produce a complex organ .can hardly be considered real..

Digital organisms don't have complex organs such as eyes, but they can
process information in complex ways. In order to add two numbers together,
for example, a digital organism needs to carry out a lot of simpler
operations, such as reading the numbers and holding pieces of those numbers
in its memory. Knock out the commands that let a digital organism do one of
these simple operations and it may not be able to add. The Avida team
realized that by watching a complex organism evolve, they might learn some
lessons about how complexity evolves in general.

The researchers set up an experiment to document how one particularly complex
operation evolved. The operation, known as equals, consists of comparing
pairs of binary numbers, bit by bit, and recording whether each pair of
digits is the same. It's a standard operation found in software, but it's not
a simple one. The shortest equals program Ofria could write is 19 lines long.
The chances that random mutations alone could produce it are about one in a
thousand trillion trillion.

To test Darwin's idea that complex systems evolve from simpler precursors,
the Avida team set up rewards for simpler operations and bigger rewards for
more complex ones. The researchers set up an experiment in which organisms
replicate for 16,000generations. They then repeated the experiment 50 times.

Avida beat the odds. In 23 of the 50 trials, evolution produced organisms
that could carry out the equals operation. And when the researchers took away
rewards for simpler operations, the organisms never evolved an equals
program. .When we looked at the 23 tests, they were all done in completely
different ways,. adds Ofria. He was reminded of how Darwin pointed out that
many evolutionary paths can produce the same complex organ. A fly and an
octopus can both produce an image with their eyes, but their eyes are
dramatically different from ours. .Darwin was right on that-there are many
different ways of evolving the same function,. says Ofria.

The Avida team then traced the genealogy leading from the first organism to
each one that had evolved the equals routine. .The beauty of digital life is
that you can watch it happen step by step,. says Adami. .In every step you
would ordinarily never see there is a goal you're going toward.. Indeed, the
ancestors of the successful organisms sometimes suffered harmful mutations
that made them reproduce at a slower rate. But mutations a few generations
later sped them up again.

When the Avida team published their first results on the evolution of
complexity in 2003, they were inundated with e-mails from creationists. Their
work hit a nerve in the antievolution movement and hit it hard. A popular
claim of creationists is that life shows signs of intelligent design,
especially in its complexity. They argue that complex things could never have
evolved, because they don't work unless all their parts are in place. But as
Adami points out, if creationists were right, then Avida wouldn't be able to
produce complex digital organisms. A digital organism may use 19 or more
simple routines in order to carry out the equals operation. If you delete any
of the routines, it can't do the job. .What we show is that there are
irreducibly complex things and they can evolve,. says Adami.

The Avida team makes their software freely available on the Internet, and
creationists have downloaded it over and over again in hopes of finding a
fatal flaw. While they've uncovered a few minor glitches, Ofria says they
have yet to find anything serious. .We literally have an army of thousands of
unpaid bug testers,. he says. .What more could you want?.


When you walk into a forest, the first thing you see is diversity. Trees
tower high overhead, ferns lurk down below, vines wander here and there like
tangled snakes. Yet these trees, ferns, and vines are all plants, and as
such, they all make a living in the same way, by catching sunlight. If one
species was better than all the rest at catching sunlight, then you might
expect it to outcompete the other plants and take over the forest. But it's
clear that evolution has taken a different course.

Figuring out why is a full-time job for a small army of biologists. A number
of them seek enlightenment by comparing places that are rich and poor in
species and trying to figure out the other things that make them different.
One intriguing pattern has to do with food. Ecologists have found that the
more energy a habitat can provide organisms, the more species it can support.
But a habitat can get too productive. Then it supports fewer species. This
pattern has emerged time and again in studies on ecosystems ranging from
grasslands to Arctic tundra.

Until recently, a typical Avida experiment would end up with a single
dominant organism. The Avida researchers suspected that was the result of
providing an endless supply of food-in this case, numbers. Perhaps, they
reasoned, if they put their digital organisms on a diet, they might evolve
into different forms-just as it happens in nature. So the Avida team retooled
their software to limit the supply of numbers flowing into their digital
worlds. Then they made the numbers even more scarce by splitting them up into
smaller supplies, each of which could be used only for a particular
operation, such as adding two numbers. As the organisms used the numbers at a
faster rate, they got a smaller benefit. And if too many organisms gorged
themselves on one supply of numbers, they would stop replicating altogether.

The Avida team subsequently flooded some digital worlds with numbers and
limited others to a scant supply, and the same pattern of diversity found in
global ecosystems emerged. When the number supply was low, only one type of
organism could survive. At intermediate levels, three or four different types
emerged and coexisted. Each type evolved into a specialist atone or a few
kinds of operations. But when the number supply got too abundant, diversity
dropped to a single species again.

Bringing diversity into Avida has brought more bad news for those who think
complexity cannot evolve. Ofria decided to run the complexity experiment over
again, this time with a limit on the supply of numbers. .It just floored me,.
he says. .I went back and checked this so many ways.. In the original
experiment, the organisms evolved the equals routine in 23 out of 50 trials.
But when the experiment was run with a limited supply of numbers, all the
trials produced organisms that could carry out the equals routine. What's
more, they needed only a fifth of the time to do it.

Ofria suspects that the difference comes from the fact that several species
are now evolving in the experiment rather than just one. More species mean
more opportunities for success.


Human society depends on countless acts of cooperation and personal
sacrifice. But that doesn't make us unique. Consider Myxococcus xanthus, a
species of bacteria that Lenski and his colleagues study. Myxococcus travels
in giant swarms 100,000strong, hunting down E. coli and other bacteria like
wolves chasing moose. They kill their prey by spitting out antibiotics, then
spit out digestive enzymes that make the E. coli burst open. The swarm then
feasts together on the remains. If the Myxococcus swarm senses that they've
run out of prey to hunt, they gather together to form a stalk. The bacteria
at the very top of the stalk turn into spores, which can be carried away by
wind or water to another spot where they can start a new pack. Meanwhile, the
individuals that formed the stalk die.

This sort of cooperation poses a major puzzle because it could be undermined
by the evolution of cheaters. Some bacteria might feast on the prey killed by
their swarm mates and avoid wasting their own energy making antibiotics or
enzymes. Others might evolve ways of ensuring that they always end up
becoming spores and never get left behind in the dead stalk. Such cheaters
are not theoretical: Lenski and his colleagues have evolved them in their

The Avida team is now trying to address the mystery of cooperation by
creating new commands that will let organisms exchange packages of
information. .Once we get them to communicate, can we get them to work
together to solve a problem?. asks Ofria. .You can set up an information
economy, where one organism can pay another one to do a computation for it..

If digital organisms cooperate, Ofria thinks it may be possible to get them
working together to solve real-world computing problems in the same way
Myxococcus swarms attack their prey. .I think we'll be able to solve much
more complex problems, because we won't have to know how to break them down.
The organisms will have to figure it out for themselves,. says Ofria. .We
could really change the face of a lot of computing..


Birds do it, bees do it, and even fleas do it-but why they all do it is
another matter. Reproduction is possible without sex. Bacteria and protozoa
simply split in two. Some trees send shoots into the ground that sprout up as
new trees. There are even lizard species that are all female. Their eggs
don't need sperm to start developing into healthy baby female lizards.

.One of the biggest questions in evolution is, why aren't all organisms
asexual?. says Adami. Given the obvious inefficiency of sex, evolutionary
biologists suspect that it must confer some powerful advantage that makes it
so common. But they have yet to come to a consensus about what that advantage

So Dusan Misevic, a biologist at Michigan State, has spent the past couple of
years introducing sex into Avida. While digital sex may lack romance, it
features the most important element from an evolutionary point of view: the
genetic material from two parents gets mixed together in a child. When a
digital organism makes a copy of itself, the copy doesn't immediately take
its own place in Avida and start reproducing. Instead, chunks of its code are
swapped with the copy of another new organism. Only after this exchange do
the two creatures start to reproduce.

In 1964 the German biologist H. J. Muller proposed that sex allows organisms
to mix their genomes together in combinations that can overcome the effects
of harmful mutations. Asexual organisms, on the other hand, are stuck with
all the mutations their ancestors pass down to them. Over time, Muller
argued, they can't reproduce as quickly as their sexual competitors. Misevic
designed an experiment to put Muller's hypothesis to the test.. It's a
classic explanation, so it seemed like a good place to start,. he says.

Misevic created two kinds of worlds: one full of sexual digital organisms and
the other full of asexuals. After they had evolved for tens of thousands of
generations, he measured how fast they could replicate. .The overall
conclusion we got was that, yes, there are some situations where sex is
beneficial,. says Misevic. But there were surprises. Sex is good mainly as a
way to escape annihilation from lethal mutations. But in Avida, sexual
organisms had to pay a price for that insurance-they carried more nonlethal
yet harmful mutations than the asexual organisms.

.We must look to other explanations to help explain sex in general,. says


Life on Earth is based on DNA. But we can't exclude the possibility that life
could evolve from a completely different system of molecules. And that raises
some worrying questions about the work going on these days to find signs of
extraterrestrial life. NASA is funding a wide range of life-detecting
instruments, from rovers that prowl across Mars to telescopes that will gaze
at distant solar systems. They are looking for the signs of life that are
produced on Earth. Some are looking for high levels of oxygen in the
atmospheres of other planets. Others are looking for bits of DNA or fragments
of cell walls. But if there's non-DNA-based life out there, we might overlook
it because it doesn't fit our preconceptions.

.We can look at how known life-forms leave marks on their environment,. says
Evan Dorn, a member of Chris Adami's lab at Caltech, .but we can never make
universal statements about them because we have only one example..

Dorn says Avida is example number two. By finding patterns that are shared by
life on Earth and life in Avida, he thinks he will be able to offer some
ideas about how to look for life that the universe might be harboring.

Some researchers have suggested the best way to look for signs of life is to
look for weird chemistry. Take the building blocks of proteins-amino
acids-which are found on meteorites and can also be created in the lab simply
by running an electric current through ammonia and other compounds. In a
lifeless setting, the most common amino acid that results is the simplest:
glycine. Some slightly less simple amino acids are also common, but all the
larger ones make up only a trace or are missing altogether. That's because it
takes a lot of energy to make those big amino acids. .There's a limited
repertoire of chemistry in the absence of life,. says Dorn.

If you analyze a scoop of soil or pond water, however, you'll find a
completely different profile of amino acids. Life has evolved ways of
building certain big amino acids, and when organisms die, those big amino
acids float around in the environment.

What if life on another planet made compounds that were radically different
from amino acids? Would it alter its planet's chemistry in some similar way?

To test this idea, Dorn created a world devoid of life. Instead of containing
a self-replicating program, each cell contained random assortment of
commands. All of the commands in the Avida language were present at equal
levels. Here was the signature of a lifeless planet.

Then Dorn began dropping organisms into this world, like spores falling to
Earth. At the beginning of the experiment, he set the mutation rate so high
that no spore could replicate very long on the planet. (Think of Mars, where
ultraviolet rays pelt the surface.) Gradually, he lowered the mutation rate
until life could survive. .As soon as the environment was habitable, the
organism took over and dominated the environment,. Dorn says.

As the digital organisms evolved to adapt to the world, Dorn found that some
commands became rare and others became far more common. This distinctive
signature stayed stable as long as life could survive on the planet. And no
matter how many times Dorn repeated the experiment, the same signature of
life appeared. Whether manipulating amino acids or computer commands, life
does seem to leave the same mark. .It gives us a pretty strong indication
that this process is universal,. says Dorn.

If Dorn is right, discovery of non-DNA life would become a little less
spectacular because it would mean that we have already stumbled across it
here on Earth-in East Lansing, Michigan.


One of the hallmarks of life is its ability to evolve around our best efforts
to control it. Antibiotics, for example, were once considered a magic bullet
that would eradicate infectious diseases. In just a few decades, bacteria
have evolved an arsenal of defenses that make many antibiotics useless.

Ofria has been finding that digital organisms have a way of outwitting him as
well. Not long ago, he decided to see what would happen if he stopped digital
organisms from adapting. Whenever an organism mutated, he would run it
through a special test to see whether the mutation was beneficial. If it was,
he killed the organism off. .You'd think that would turn off any further
adaptation,. he says. Instead, the digital organisms kept evolving. They
learned to process information in new ways and were able to replicate faster.
It took a while for Ofria to realize that they had tricked him. They had
evolved a way to tell when Ofria was testing them by looking at the numbers
he fed them. As soon as they recognized they were being tested, they stopped
processing numbers. .If it was a test environment, they said, 'Let's play
dead,' . says Ofria. .There's this thing coming to kill them, and so they
avoid it and go on with their lives..

When Ofria describes these evolutionary surprises, admiration and ruefulness
mix in is voice. .Here I am touting Avida as a wonderful system where you
have full knowledge of everything and can control anything you want-except I
can't get them to stop adapting. Life will always find a way..

Thinking about such adaptable creatures lurking on the Michigan State campus,
furiously feeding on data, can be unsettling. Should the Avida team be
working in quarantine? Lenski argues that Avida itself acts as a quarantine,
because its organisms can exist only in its computer language. .They're
living in an alien world,. Lenski says. .They may be nasty predators from
Mars, but they'd drop dead here..

Still, Ofria acknowledges that harmful computer viruses may eventually evolve
like his caged digital organisms. .Some day it's going to happen, and it's
going to be scary,. Ofria says. .Better to study them now so we know how to
deal with them..

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