[Paleopsych] BH: Anti-sleeping Pill Might Cut Cocaine Habit
checker at panix.com
Thu Feb 3 20:14:34 UTC 2005
Anti-sleeping Pill Might Cut Cocaine Habit
1/10/2005 8:00 PM
Treatment option? A new study has found that the narcolepsy drug
modafinil helps people overcome cocaine addiction
A wake-promoting agent could find a new use as one of the few drugs
able to treat cocaine dependence.
According to American researchers at the University of Pennsylvania
School of Medicine, despite years of research there are still no
approved drugs for treating cocaine addiction. The wake-promoting
drug modafinil (Provigil), however, which is approved for
treating narcolepsy, has attracted attention for its ability to
blunt cocaine-induced euphoria.
Charles Dackis of the University of Pennsylvania and colleagues
have now reported a double-blind, placebo-controlled trial that found
modafinil promoted cocaine abstinence in treatment-seeking
outpatients. "If confirmed by further investigation, this could be the
breakthrough we have been waiting for," says Dackis.
Conducted between 2002 and 2003, the study involved 62
cocaine-dependent people aged 25 to 63 who were free of significant
health conditions. Thirty participants received a single 400 mg dose
of modafinil in the morning while 32 were giving matching placebo
tablets. Treatment continued for eight weeks along with twice-weekly
cognitive behavioral therapy.
The researchers measured the treatment's primary effectiveness by
cocaine abstinence based on urine toxicity testing. They also measured
secondary effects such as the drug's impact on cravings and adverse
Over the eight-week study, people treated with modafinil provided more
cocaine-negative urine samples than those on placebo and were more
likely to achieve abstinence. The researchers also found no adverse
effects in those receiving modafinil, and no participant failed to
complete the study due to side-effects.
Three larger studies examining modafinil for cocaine dependence are
The research is reported in the journal Neuropsychopharmacology
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