[Paleopsych] A rich resource on cellular receptors
Steve Hovland
shovland at mindspring.com
Mon May 2 00:23:29 UTC 2005
http://www.answers.com/main/ntquery;jsessionid=3ss6ltts54wlo?method=4&ds
id=2222&dekey=Receptor+%28biochemistry%29&gwp=8&curtab=2222_1&sbid=lc03b
receptor (biochemistry)
In biochemistry, a receptor is a protein on the cell membrane or within the
cytoplasm that binds to a specific factor (a ligand), such as a
neurotransmitter, hormone, or other substance, and initiates the cellular
response to the ligand. As all receptors are proteins, their structure is
encoded into the DNA. Most hormone genes contain a short sequence that
signals to the cell whether it needs to be transported to the cell membrane
or it is to remain in the cytoplasm.
Overview
Many genetic disorders involve hereditary defects in receptor genes. Often,
it is hard to determine whether the receptor is nonfunctional or the
hormone is produced at decreased level; this gives rise to the
"pseudo-hypo-" group of endocrine disorders, where there appears to be a
decreased hormonal level while in fact it is the receptor that is not
responding sufficiently to the hormone.
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