[extropy-chat] antiaging paper

[BillK]

On Tue, 28 Sep 2004 10:22:52 -0400, Joao Magalhaes wrote:
> As I've said many times, findings in yeast do not necessarily imply similar
> findings in mammals. There are many ways to extend lifespan in yeast and
> yet these have not been implicated in mammalian aging--except perhaps
> caloric restriction but even so the mechanisms of CR in yeast and rodents
> appear to be different. Now, you do mention that the lifetime of rats was
> extended by 50% but that is not in the papers you cite. Where did you read
> the results from rats? There have been studies with SOD2 in mice and rats
> but, as far as I know, these have NOT extended normal lifespan. You can
> check out:
> 
> http://genomics.senescence.info/genes/entry.php?hugo=sod2
> 

There is a 'pop' writeup on Betterhumans at:
<http://www.betterhumans.com/News/news.aspx?articleID=2004-09-27-3>

This confirms what Joao says that it is pure speculation that the
yeast results might possibly apply to mammals.

Quote:
Longo admits that programmed human aging is just a possibility. "We
don't know whether it's true yet or not," he says. "But if aging is
programmed in yeast, and the pathway is very similar, then isn't it
possible that humans also die earlier than they have to?"
Longo admits there are many unanswered questions in his theory and
plans to look closer at aging in humans and mammals.

There are various reports that CR diets and including other nutrients
and hormones in rats diets can extend lifespan by up to 50%, but in
this 'snake-oil' area you have to be very careful what you read.


BillK