[ExI] you cn't always get what you wnt
David C. Harris
dharris234 at mindspring.com
Sun Aug 12 02:59:49 UTC 2007
Executive summary: young blood contains something that makes at least
some tissues act younger.
I don't know for sure if it's old news (see Jeff's message below), but I
didn't know this observation, even though I have graduate training in
biochemistry/molecular biology/health services administration, and
follow stem cell issues relevant to my investment in Geron.
Did others recognize the implications of this pair of quotes?:
> "The work was done with live mice whose circulatory systems were
> joined, and in lab dishes with young cells immersed in serum from old
> "... confirmed their earlier research showing that the ability of
> muscle stem cells to regenerate tissue depends on the age of the
> cells' environment (including the age of the blood supplying the
> tissue), not the age of the stem cell.
> Although Rando's research focused on the repair of acute trauma to
> muscles, he suspects that the same sort of problem arises on a lesser
> scale in repairing damage that results from the normal wear and tear
> of aging."
As I read that, with my creative streak being exposed, it suggests
vampires had it wrong in their search for immortality. Rather than
DRINKING blood, they should have arranged transfusions of young
Putting on my health care hat (I'm trained as a biochemist and health
administrator) to say it directly, those two quotes suggest that aging
might be slowed by getting transfusions of young blood (or a factor that
might be extracted or synthesized by genetic engineering methods),
perhaps available at a high price NOW. The FDA couldn't stop an
underground trade in young blood.
As a research endeavor, I wonder if the blood bank records allow one to
track the age of blood donors, and the subsequent speed of recovery of
Obviously we could do some original work with purebred mice (so no
problem of transfusion rejection) of various ages. And I wonder if
umbilical cord blood, which is rarely harvested now, might have enhanced
effect per volume.
In the general search for regeneration and enhanced longevity, this
discovery suggests a flood of productive searches for factors that
activate regeneration of human tissues. Blood is easy to isolate and
infuse. And as a matter of policy, I think it's time to allow the open
and well regulated sale of blood, and later other tissues and organs.
With a radio frequency ID (RFID) chip going along with each
well-characterized blood unit, healthy donors can ask for higher
payments, and the "blood shortages" will disappear as supply comes up to
- David Harris, Palo Alto, California.
Jeff Davis wrote:
> Is this old news?
> Stanford researchers find culprit in aging muscles that heal poorly
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