[ExI] you cn't always get what you wnt

Jeff Davis jrd1415 at gmail.com
Sun Aug 12 19:44:27 UTC 2007

On 8/12/07, Jeff Davis <jrd1415 at gmail.com> wrote:
> Is this old news?
> Stanford researchers find culprit in aging muscles that heal poorly
> http://www.eurekalert.org/pub_releases/2007-08/sumc-srf080607.php

In posting the link, I restrained myself from saying more.  I was
tempted, but thought to avoid embarrassing myself.

It seemed to me that a modest extrapolation of the salient point --
the effect of Wnt  becomes destructive with age -- leads to a rather
dramatic notion/tentative implication:  Hooray! Yippee! (Jumping
around wildly, waving arms, vocalizing uncontrollably (laughing,
chirping, and gibbering while intermittantly drooling and broadcasting
spittle with a degree of  radial symmetry) We've  found it!  We've
found it!  The fountain of youth!  The secret to eternal life!!
Immortality is ours!!

Suppress the Wnt signal.

Quoting from the article:

"...one could envision this becoming a therapeutic."

How very discreet that.

Rando said many drugs can block Wnt signaling. "Theoretically, given
the number of ways to block Wnt and Wnt signaling, one could envision
this becoming a therapeutic," he said. "You could potentially enhance
the healing of aged tissues by reducing this effect of Wnt signaling
on the resident stem cells."

"Enhance."  Yeah, that's the ticket.  Enhance me.  Please.

Best, Jeff Davis

               "Everything's hard till you
                     know how to do it."
                              Ray Charles

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