[ExI] embryonic neurons
David C. Harris
dharris at livelib.com
Sat Oct 17 09:05:53 UTC 2009
Could you give a citation of a URL or refereed paper on this topic?
Alan Brooks wrote:
> Embryonic neurons are unusual in that they are able to extend neurites
> quite efficiently in extracellular environments that do not support
> the migration of other motile cell types.
> Recent work in the laboratory has shown that embryonic sensory neurons
> are able to compensate for inhibitory or weakly growth-promoting
> substrata by adjusting their expression of receptors for
> growth-promoting matrix molecules (receptors of the integrin class).
> Cell-surface integrin levels appear to be modulated either through a
> post-translational mechanism of targeted endocytosis or through
> activation of a receptor-based second messenger system. Regulated
> integrin expression in response to the extracellular environment may
> be required for neurons (and possibly for other invasive cell types)
> to migrate into diverse tissues.
> The regenerative failure of adult CNS neurons may be in part due to
> changes in integrin expression associated with the maturation of
> neurons to an adult phenotype. The regeneration of adult neurons in
> culture can be greatly improved by transgenic integrin expression.
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