[ExI] Cryonics punched cards and the brain

[Anders Sandberg]

Neat. Generally LTP is seen as the first of a longer cascade of fixation 
of memories. Most research has been about cellular skeleton changes, but 
perineuronal nets might also work.

It might actually be a good experiment for cryonics to see what the 
process does to these nets. (I think John mixed up the perioneuronal net 
(protein networks) with perineuronal space in the sleep reference. )


Incidentally, the Sejnowski lab had a nice result on the distribution of 
synaptic strengths:
Bartol, T. M. Jr. Bromer, C. Kinney, J. P. Chirillo, M. A. Bourne, J. N. 
Harris, K. M. Sejnowski, T. J. 
<http://papers.cnl.salk.edu/index.php?SearchText=Bartol%2C%20T.%20M.%20Jr.%20Bromer%2C%20C.%20Kinney%2C%20J.%20P.%20Chirillo%2C%20M.%20A.%20Bourne%2C%20J.%20N.%20Harris%2C%20K.%20M.%20Sejnowski%2C%20T.%20J.>Nanoconnectomic 
upper bound on the variability of synaptic plasticity, eLife, 4:e10778, 2015
http://papers.cnl.salk.edu/PDFs/Nanoconnectomic%20upper%20bound%20on%20the%20variability%20of%20synaptic%20plasticity%202015-4475.pdf
They show that each synapse stores at most about 4.7 bits. While their 
press material claims this is "an order of magnitude more" than previous 
estimates, the actual estimate most people have been doing is about one 
bit, so the difference isn't dramatic. But doing nanoconnectomics is an 
awesome method.

-- 
Dr Anders Sandberg
Future of Humanity Institute
Oxford Martin School
Oxford University

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