[ExI] Autophagy and Aging

Stuart LaForge avant at sollegro.com
Sat May 4 23:01:21 UTC 2019

BillK wrote:

> <big snip>
>> Anyways, water only fasting every other day is working for me so I
>> thought I would share.
> This sounds very much like the Alternate-day Fasting Diet, which has
> become quite popular (among many other diet plans, of course).
> Search for - alternate day fasting diet - for many articles.

Actually it is the strictness of the fasting portion of LEAD that  
distinguishes from previous iterations of alternate day fasting. Most  
such ALternate Day Fasting (ADF) diets allow eating some protein or  
carbs during the fasting days. While one can still lose weight this  
way, losing weight is but a positive side effect of the Life Extending  
Autophagic Diet (LEAD), The primary goal of LEAD is to recycle your  
body's proteins completely through repeated cycles of autophagy which  
requires strictly limiting carbs and proteins to eating days and not  
fasting days.

> I found a small study done in 2017 -----
> Effect of Alternate-Day Fasting on Weight Loss, Weight Maintenance,
> and Cardioprotection Among Metabolically Healthy Obese Adults  A
> Randomized Clinical Trial
> John F. Trepanowski, PhD1; Cynthia M. Kroeger, PhD1,2; Adrienne
> Barnosky, MD1; et al
> <https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2623528>
> -----------
> It doesn't seem to do any harm, but may not be better than a
> general calorie restriction diet.

I want to point out two things. First according to the study's methods:

"Interventions  Participants were randomized to 1 of 3 groups for 1  
year: alternate-day fasting (25% of energy needs on fast days; 125% of  
energy needs on alternating “feast days”), calorie restriction (75% of  
energy needs every day), or a no-intervention control. The trial  
involved a 6-month weight-loss phase followed by a 6-month  
weight-maintenance phase."

25% of energy needs on fast days means they ate a few hundred calories  
on their fast days and it was unlikely to be pure fat as it would be  
under my system.

Secondly, if you look at Table I in the article, the Alternate Day  
Fasting group had lower insulin levels than did either the Calorie  
Restriction Group or the Control Group.

Stuart LaForge

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