[extropy-chat] Aspirin, life-extension, and the current spate of pain-reliever problems

[Samantha Atkins]

It is indeed wondrous scary  how fast a query sometimes gets answered 
here!

I had a very drastic ankle injury two decades ago that often acts up 
and is getting more arthritic over time.  For a while I was taking 
Celebrex nearly every day.   I stopped taking it some months back as I 
did not like the list of possible side-effects.  I found that careful 
exercise and build up of strength in the injured leg did more to 
increase the time between flare-ups and lessen the severity.

I stopped taking aspirin for two reasons:

a) members of my family die from bleed-outs (various type of 
hemorrhage) more often than from clotting problems;

b) I started and am maintaining an aerobic and strength training 
program that further decreases risk.

-s

On Dec 21, 2004, at 6:48 PM, Dan Clemmensen wrote:

> Damien Broderick wrote:
>
>> Here's a response to Dan's interesting suggestion from Steve Harris, 
>> MD:
>>
>> ==============
>>
>> COX-1 is the form of the enzyme found in all tissues. COX-2
>> is the form which is induced by, and contributes to, acute
>> inflammation, but otherwise is normally not active (except
>> in uninflammed kidney and brain, for reasons not obvious).
>
> [Snip]
>
> Thanks, Damien.
>
> extropy-chat is scary. In less than four hours, I received a highly 
> competent response to a theoretical question. I had of course 
> attempted to answer the question using Google before I asked the list.
>
> What Steve is saying is that Aspirin iinhibits Cox-1 and Cox2 at the 
> same time. Users of Viaoxx and other Cox-1 inhibitors are losing 
> Aspirin's inhibitory effect on Cox-1. Inhibiting Cox-2 results in 
> reductions of inflammation, while inhibiting Cox-1 had other effects, 
> both "good" and "bad."
>
> Steve, as a practicing MD, prescribes Aspirin to any patient taking 
> Viaoxx ( and for whom Aspirin is not counterindicated.) This says that 
> my hypothesis was pretty damn obvious to real-life practitioners.
>
> The moral of this story is: don't inhibit Cox-2 unless you also 
> inhibit Cox-1.
>
> Survey: how many extropians are taking Aspirin?
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