[extropy-chat] Caloric restriction benefits limited in humans

[Joao Magalhaes]

A few people have recently come out against the benefits of CR in people, 
including Aubrey. I'm a bit skeptical myself. I mean, I hope everybody 
knows that a low calorie diet is healthier while a high calorie diet could 
lead to obesity, diabetes, etc. That doesn't mean CR will work in people 
the way it does in mice, which BTW are very short-lived animals and hence 
the evolutionary forces acting on them to deal with periods of food 
shortage may be different than in humans because these periods in mice will 
be a larger proportion of the whole lifespan. My general advice is always 
that people should take attention to what they eat but don't exaggerate. I 
expect CR to make people live a little bit longer by decreasing the 
incidence of a number of diseases, but whether CR will delay aging in 
people like it does in mice is unlikely.

Joao

At 12:48 PM 31/8/2005, you wrote:
>[Robert Bradbury elsewhere sez:]
>
>John Phelan and Michael Rose have published an article in
>Ageing Research Reviews that indicates that caloric restriction
>in humans is probably of marginal benefit.  See [1,2].
>
>Robert
>
>1. 
>http://www.sciencedaily.com/print.php?url=/releases/2005/08/050830065729.htm
>2. Phelan JP, Rose MR, "Why dietary restriction substantially increases 
>longevity
>in animal models but won't in humans."  Ageing Res Rev. 4(3):339-50 (Aug 
>2005).
>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16046282
>
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