[ExI] Alcohol meta-analysis
Max More
max at maxmore.com
Tue Jun 9 05:27:05 UTC 2009
Thanks for posting that, Emlyn. These researchers
(who seem to have several meta-analyses of
alcohol) did find some protective effect of
alcohol for coronary heart disease -- but not for anything else.
Now I'll have to try to figure out how many normal drinks 72g of ethanol is...
A meta-analysis of alcohol consumption and the risk of 15 diseases.
<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Corrao%20G%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus>Corrao
G,
<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Bagnardi%20V%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus>Bagnardi
V,
<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Zambon%20A%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus>Zambon
A,
<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22La%20Vecchia%20C%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus>La
Vecchia C.
Dipartimento di Statistica, Università di Milano-Bicocca, Milan, Italy.
BACKGROUND: To compare the strength of evidence
provided by the epidemiological literature on the
association between alcohol consumption and the
risk of 14 major alcohol-related neoplasms and
non-neoplastic diseases, plus injuries. METHODS:
A search of the epidemiological literature from
1966 to 1998 was performed by several
bibliographic databases. Meta-regression models
were fitted considering fixed and random effect
models and linear and nonlinear effects of
alcohol intake. The effects of some
characteristics of the studies, including an
index of their quality, were considered. RESULTS:
Of the 561 initially reviewed studies, 156 were
selected for meta-analysis because of their a
priori defined higher quality, including a total
of 116,702 subjects. Strong trends in risk were
observed for cancers of the oral cavity,
esophagus and larynx, hypertension, liver
cirrhosis, chronic pancreatitis, and injuries and
violence. Less strong direct relations were
observed for cancers of the colon, rectum, liver,
and breast. For all these conditions, significant
increased risks were also found for ethanol
intake of 25 g per day. Threshold values were
observed for ischemic and hemorrhagic strokes.
For coronary heart disease, a J-shaped relation
was observed with a minimum relative risk of 0.80
at 20 g/day, a significant protective effect up
to 72 g/day, and a significant increased risk at
89 g/day. No clear relation was observed for
gastroduodenal ulcer. CONCLUSIONS: This
meta-analysis shows no evidence of a threshold
effect for both neoplasms and several
non-neoplastic diseases. J-shaped relations were
observed only for coronary heart disease.
-------------------------------------
Max More, Ph.D.
Strategic Philosopher
Extropy Institute Founder
www.maxmore.com
max at maxmore.com
-------------------------------------
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